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Fig. 3 | Parasites & Vectors

Fig. 3

From: Contribution of tissue transglutaminase to the severity of hepatic fibrosis resulting from Schistosoma japonicum infection through the regulation of IL-33/ST2 expression

Fig. 3

tTG knockout down-regulated the expression level of IL-33/ST2. a The protein level of IL-33 and ST2 in mice liver homogenates detected by Western blotting is shown on the left panel, and semi-quantitative analysis is displayed on the right panel. GAPDH was used as a loading control. b, c The protein expression levels and localization of IL-33 (b) and ST2 (c) in mice liver tissue were determined by IHC assay (200× and 400× (insets); scale-bar: 50 μm), and the quantification of the signal using modified H score analysis is shown on the right. Data are presented as the mean ± SEM from 3–6 mice per group. All in vitro experiments were performed three times. Red arrows indicate the Sj eggs (t-test, *P = 0.0360, ****P < 0.0001)

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