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Table 1 Clearance parameters for post-treatment dynamics of LDH, Aldo, and HRP2 proteins from P. falciparum-infected children in Angola

From: Clearance dynamics of lactate dehydrogenase and aldolase following antimalarial treatment for Plasmodium falciparum infection

  LDH Aldo HRP2
Day 0 concentration (pg/ml), median (IQR) 555,255 (219,090–1,803,141) 35,758 (12,378–73,830) 699,256 (287,765–1,429,700)
Day 2 concentration (pg/ml), median (IQR)a 2559 (472–15,766) 1168 (594–2975) 421,035 (165,200–874,968)
Reduction from Day 0 to Day 2 (%), median (95% CI)a 99.7 (99.5–99.8) 96.32 (95.81–96.82) 54.63 (44.65–62.61)
Decay rate pre-Day 2 (λ1), d−1, median (95% CI)a 2.8 (2.6–3.0) 1.7 (1.6–1.7) 0.4 (0.30–0.49)
Decay rate post-Day 2 (λ2), d−1, median (95% CI)a 0.38 (0.31–0.45) 0.21 (0.20–0.23) 0.15 (0.14–0.15)
Variation in concentration (σ), median (95% CI)a 1.83 (1.83–1.83) 1.02 (0.94–1.13) 1.3 (1.2–1.3)
Half-life post-Day 2 (d), median (95% CI)a 1.8 (1.5–2.3) 3.2 (3.0–3.4) 4.8 (4.7–4.9)
  1. Abbreviations: IQR: interquartile range; CI: credible interval; LDH: lactate dehydrogenase; Aldo: Aldolase; HRP2: histidine-rich protein 2; d: day
  2. aEstimates calculated using observed and imputed values