Table 3 ROC curve analyses of metabolites to identify HAE patients

Serum

 Glutamate

100.00

88.89

0.924 (0.802–1.000)

 Valine

94.44

88.89

0.920 (0.804–1.000)

 Leucine

77.78

88.89

0.920 (0.801–0.981)

 Phenylalanine

88.89

94.44

0.914 (0.782–1.000)

 Creatine

83.33

88.89

0.870 (0.731–0.981)

 Isoleucine

83.33

72.22

0.852 (0.716–0.951)

 Lysine

83.33

77.78

0.849 (0.665–0.974)

 Formate

77.78

88.89

0.833 (0.676–0.960)

 Betaine

77.78

83.33

0.824 (0.684–0.948)

 Serine

83.33

77.78

0.824 (0.676–0.941)

 1-methylhistidine

72.22

77.78

0.785 (0.627–0.914)

 Tyrosine

83.33

72.22

0.782 (0.609–0.924)

 Lactate

83.33

77.78

0.762 (0.590–0.911)

 Glutamine

66.67

83.33

0.716 (0.532–0.873)

Urine

 Glutamate

77.78

77.78

0.864 (0.714–0.957)

 Creatinine

83.33

88.89

0.816 (0.645–0.952)

 p-hydroxyphenylacetate

72.22

88.89

0.815 (0.611–0.955)

 3-hydroxybutyrate

77.78

72.22

0.793 (0.619–0.914)

 Malate

72.22

83.33

0.781 (0.614–0.920)

 Glycolate

66.67

77.78

0.772 (0.572–0.900)

 γ-aminobutyrate

72.22

72.22

0.769 (0.586–0.903)

 3-methylhistidine

72.22

77.78

0.765 (0.591–0.920)