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Fig. 3 | Parasites & Vectors

Fig. 3

From: A novel praziquantel solid lipid nanoparticle formulation shows enhanced bioavailability and antischistosomal efficacy against murine S. mansoni infection

Fig. 3

Computer-adjusted drug dose-response curves for M-PZQ and SLN-PZQ. The curves were fitted to results calculated using GraphPad Prism software v.6.01 and were plotted assuming that all had a minimum of 0% and a maximum of 100%. *Significant worm reduction in S. mansoni-infected mice treated with SLN-PZQ and M-PZQ vs the corresponding infected untreated controls at P < 0.05. Significant worm reduction in S. mansoni-infected mice treated with SLN-PZQ vs that in mice treated with M-PZQ at P < 0.05. Abbreviations: SLN-PZQ, solid lipid nanoparticle praziquantel; M-PZQ, market praziquantel; ED95, effective dose required to kill 95% of adult worms

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