SLN formula
|
Composition of SLN formulations
|
Physicochemical properties
|
---|
Labrafil: Plurol oleique
|
Lauroglycol 90 (mg)
|
Labrasol (mg)
|
Particle size (nm)a
|
PDI
|
ZP (mV)
|
EE (%)a
|
---|
F1
|
1:1
|
0.1
|
0.1
|
285.45 ± 4.39
|
0.843
|
− 14.5
|
5.46 ± 0.23
|
F2
|
1:3
|
0.1
|
0.1
|
302.3 ± 5.27
|
0.657
|
− 17.3
|
3.02 ± 0.11
|
F3
|
1:5
|
0.1
|
0.1
|
123.5 ± 2.19
|
0.675
|
− 18.5
|
32.04 ± 2.19
|
F4
|
1:1
|
0.1
|
0.2
|
140.4 ± 2.49
|
0.654
|
− 23.4
|
31.12 ± 3.02
|
F5
|
1:3
|
0.1
|
0.2
|
155.3 ± 3.01
|
0.765
|
− 24.6
|
54.56 ± 4.28
|
F6
|
1:5
|
0.1
|
0.2
|
133.6 ± 8.22
|
0.546
|
− 26.4
|
91.26 ± 3.39
|
F7
|
1:1
|
0.1
|
0.4
|
105.3 ± 4.39*
|
0.314
|
− 35.2
|
109.21 ± 2.83*
|
F8
|
1:3
|
0.1
|
0.4
|
87.32 ± 5.19*
|
0.432
|
− 38.3
|
101.12 ± 3.28*
|
F9
|
1:5
|
0.1
|
0.4
|
118.4 ± 7.10*
|
0.321
|
− 35.4
|
100.23 ± 1.46*
|
- Notes: Praziquantel-loaded SLNs were composed of plurol oleique (P.O.), Labrafil and Lauroglycol 90 as core matrices Labrasol in 10 ml distilled water was incorporated at concentrations of 0.1, 0.2 or 0.4 mg to each of the three Labrafil:plurol oleique ratios. Physiochemical properties were assessed for each formulation
- aValues represent the means ± standard deviation (SD)
- * Significant differences from the different SLN formulations at P < 0.05
- Abbreviations: SLN, solid lipid nanoparticle; PDI, polydispersity index; ZP, zeta potential; EE, entrapment efficiency