Table 3 Serodiagnostic performance of recombinant E. granulosus antigen Bs (rEgAgBs) against serum samples from different stages of cystic echinococcosis (CE) and alveolar echinococcosis (AE) cases
| Â | No. tested | No. positive (%) | ||||
|---|---|---|---|---|---|---|
rEgAgB1 | rEgAgB2 | rEgAgB3 | rEgAgB4 | rEgAgB5 | ||
CE1 | 26 | 21 (80.8) | 24 (92.3) | 23 (88.5) | 16 (61.5) | 21 (80.8) |
CE2 | 19 | 16 (84.2) | 18 (94.7) | 18 (94.7) | 12 (63.2) | 14 (73.7) |
CE3a | 10 | 9 (90.0) | 10 (100) | 10 (100) | 9 (90.0) | 9 (90.0) |
CE3b | 20 | 20 (100) | 20 (100) | 20 (100) | 16 (80.0) | 15 (75.0) |
CE4 | 22 | 18 (81.8) | 20 (90.9) | 18 (81.8) | 15 (68.2) | 20 (90.9) |
CE5 | 13 | 9 (69.2) | 10 (76.9) | 10 (76.9) | 7 (53.8) | 9 (69.2) |
AE | 12 | 6 (50.0) | 4 (33.3) | 4 (33.3) | 9 (75.0) | 10 (83.3) |
Controls | 62 | 0 (0) | 0 (0) | 0 (0) | 9 (14.5) | 17 (27.4) |
Sensitivity | 110 | 93 (84.5) | 102 (92.7) | 99 (90.0) | 75 (68.2) | 88 (80.0) |
Specificity | 74 | 6 (91.9) | 4 (94.6) | 4 (94.6) | 18 (75.7) | 27 (63.5) |
AUC ± SE |  | 0.9216 ± 0.02007 | 0.9613 ± 0.01283 | 0.9517 ± 0.01641 | 0.8049 ± 0.03247 | 0.7693 ± 0.03562 |
95% CI |  | 0.8823–0.9610 | 0.9362–0.9864 | 0.9196–0.9839 | 0.7413–0.8686 | 0.6995–0.8391 |
Cut-offsa | Â | 0.1625 | 0.1760 | 0.2000 | 0.1705 | 0.1190 |
PLR | Â | 10.43 | 17.15 | 16.65 | 2.8 | 2.19 |
NLR | Â | 0.17 | 0.08 | 0.11 | 0.42 | 0.31 |
PPV (%) | Â | 93.9 | 96.2 | 96.1 | 80.7 | 76.5 |
NPV (%) | Â | 80.0 | 89.7 | 86.4 | 61.5 | 68.1 |
Youden’s index |  | 0.76 | 0.87 | 0.85 | 0.44 | 0.44 |