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Table 5 Diagnostic test results

From: Clinical aspects of visceral leishmaniasis caused by L. infantum in adults. Ten years of experience of the largest outbreak in Europe: what have we learned?

 IC-VL (n = 84)HIV-VL (n = 11)IS-VL (n = 16)Total (n = 111)P-value
RDT (rk39-ICT) (n/T, %)26/62 (42)5/10 (50)7/12 (58)38/84 (45)0.550
ELISA/iIFAT (n/T, %)77/81 (95)11/11 (100)16/16 (100)104/108 (96)0.500
Optical microscopy (bone marrow) (n/T, %)32/78 (41)5/10 (50)8/16 (50)45/104 (43)0.726
Culture (bone marrow) (n/T, %)6/28 (21)3/3 (100)3/6 (43)12/37 (32)χ2 = 8.64, df = 2, p =0.013*
PCR (bone marrow) (n/T, %)67/73 (92)9/10 (90)16/16 (100)92/99 (93)0.474
PCR (blood) (n/T, %)21/25 (84)4/4 (100)7/8 (88)32/37 (87)0.682
  1. Abbreviations: RDT (rK39-ICT), rapid diagnostic test, immunochromatographic test based on rK39 antigen; n, sample size for each group; IC-VL, visceral leishmaniasis in immunocompetent patients; HIV-VL, visceral leishmaniasis in patients with HIV; IS-VL, visceral leishmaniasis in immunosuppressed patients (receiving steroids, methotrexate, anti-TNF); n/T, number of positives/total number of tests performed