ProHeart® 12, a moxidectin extended-release injectable formulation for prevention of heartworm (Dirofilaria immitis) disease in dogs in the USA for 12 months

Table 4 Adverse reactions reported from field study on efficacy of ProHeart® 12 against Dirofilaria immitis in dogs

Adverse reaction^a	Heartgard® Plus (N = 296) n (%)	ProHeart® 12 (N = 297) n (%)
Vomiting	78 (26.4)	75 (25.3)
Lethargy	34 (11.5)	46 (15.5)
Diarrhea	46 (15.5)	43 (14.5)
Anorexia	31 (10.5)	41 (13.8)
Seizures^b	7 (2.4)	10 (3.4)
Hepatopathy	3 (1.0)	8 (2.7)
Hypersalivation^c	3 (1.0)	7 (2.4)
Anaphylactoid/hypersensitivity reaction	4 (1.4)	6 (2.0)

^aOccurrence calculated on a per dog basis. Some dogs may have experienced more than one adverse reaction or more than one occurrence of the same adverse reaction during the study
^bSeizure category includes all dog reported with epileptic seizures, convulsions and loss of consciousness. Some, but not all, dogs listed with central nervous system disorder not otherwise specified and muscle tremors are also included in this category
^cHypersalivation category includes all dogs reported with hypersalivation and gastrointestinal foreign body not otherwise specified

ISSN: 1756-3305