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Fig. 2 | Parasites & Vectors

Fig. 2

From: Molecular characterization and functional analysis of the Schistosoma mekongi Ca2+-dependent cysteine protease (calpain)

Fig. 2

Multiple sequence alignment of SmeCalp1 sequence with orthologs. The deduced amino acid sequence of calpain 1 homologs Schistosoma mekongi (SmeCalp1), S. japonicum-Chinese strain (Sj-CCalp1), S. mansoni (SmCalp1) and S. haematobium (ShCalp1) were aligned using Clustal Omega program. The identical and similar amino acids are shaded in black and gray, respectively. Gaps (−) are introduced to optimize homology. The arrows indicate the regions of domains I, II, III and IV. The cysteine protease active site is indicated by yellow dashed overline. The predicted catalytic triad cysteine (C154), histidine (H313) and asparagine (N337) is indicated by stars. Red box indicates the putative Ca2+-binding acidic loop (E-E/D-X-D-D/E-X-D-D/E-D-G-X). The four EF-hand motifs (EF1 to 4) are indicated by green overlines. The GenBank accession numbers of the sequences are provided in Additional file 2: Table S2

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