Table 4 KEGG pathways (36) with enriched downregulated terms in Culex quinquefasciatus larvae from the RIAB59 resistant colony

Metabolism

Global

 Microbial metabolism in diverse environments

9

1.14E−06

cqu01120

 Carbon metabolism

4

8.01E−03

cqu01200

Carbohydrate

 Pyruvate metabolism

6

1.51E−06

cqu00620

 Glycolysis/gluconeogenesis

4

4.76E−04

cqu00010

 Citrate cycle (TCA cycle)

3

4.59E−03

cqu00020

 Fructose and mannose metabolism

2

2.11E−02

cqu00051

 Butanoate metabolism

2

1.91E−02

cqu00650

 Glyoxylate and dicarboxylate metabolism

2

1.95E−02

cqu00630

Lipid

 Sphingolipid metabolism

3

4.06E−03

cqu00600

 Glycerophospholipid metabolism

3

1.81E−02

cqu00564

 Synthesis and degradation of ketone bodies

2

2.57E−03

cqu00072

 Ether lipid metabolism

2

1.91E−02

cqu00565

Nucleotides

 Purine metabolism

13

1.26E−10

cqu00230

 Pyrimidine metabolism

11

2.51E−10

cqu00240

Aminoacids

 Cysteine and methionine metabolism

3

2.58E−03

cqu00270

 Arginine and proline metabolism

3

1.062E−02

cqu00330

 Alanine, aspartate and glutamate metabolism

2

3.94E−02

cqu00250

 Glycine, serine and threonine metabolism

2

4.85E−02

cqu00260

Other aminoacids

 Glutathione metabolism

5

1.16E−04

cqu00480

 Selenocompound metabolism

2

5.56E−03

cqu00450

Xenobiotics biodegradation

 Metabolism xenobiotics by cytochrome P450

2

1.95E−02

cqu00980

 Drug metabolism-cytochrome P450

2

1.95E−02

cqu00982

Genetic information processing

Transcription

 Spliceosome

8

1.97E−05

cqu03040

 RNA polymerase

4

3.40E−04

cqu03020

Translation

 Ribosome biogenesis in eukaryotes

12

4.82E−11

cqu03008

 Ribosome

11

3.90E−08

cqu03010

 RNA transport

10

6.57E−07

cqu03013

Folding/sorting/degradation

 Protein processing in endoplasmic reticulum

22

7.46E−24

cqu04141

 RNA degradation

6

2.89E−05

cqu03018

 Protein export

5

4.69E−06

cqu03060

 Ubiquitin mediated proteolysis

4

1.18E−02

cqu04120

Environmental information processing

Signal transduction

 FoxO signaling pathway

3

1.91E−02

cqu04068

Membrane transport

 ABC transporters

2

1.13E−02

cqu02010

Cellular processes

Transport and catabolism

 Endocytosis

6

1.18E−04

cqu04144

 Phagosome

5

2.11E−04

cqu04145

 Peroxisome

4

4.59E−03

cqu04146