From: Safety of an extended-release injectable moxidectin suspension formulation (ProHeart® 12) in dogs
Injection site | Groupa | Degree of swellingb | Day of study | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 8 | 57 | 120 | 183 | 190 | 239 | 302 | 365 | 372 | 379 | |||
Day 1 | Controlc | None | 6 | 6 | 8 | 8 | 8 | 8 | 8 | 8 | 6 | 8 | 8 |
Very slight | 2 | 2 | – | – | – | – | – | – | 2 | – | – | ||
0.5 mg/kg | None | – | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | |
1.5 mg/kg | None | – | 8 | 8 | 6 | 5 | 4 | 6 | 6 | 1 | 1 | 4 | |
Very slight | – | – | – | 2 | 2 | 2 | 1 | – | 3 | 3 | 3 | ||
Slight | – | – | – | – | 1 | 2 | 1 | 2 | 4 | 4 | 1 | ||
2.5 mg/kg | None | – | 6 | 7 | 7 | 3 | 7 | 7 | 4 | 1 | 1 | 5 | |
Very slight | – | 2 | 1 | 1 | 3 | – | – | 2 | 2 | 3 | 1 | ||
Slight | – | – | – | – | 2 | 1 | 1 | 2 | 5 | 4 | 2 | ||
Day 183 | Control | None | – | – | – | – | 8 | 7 | 7 | 8 | 7 | 8 | 8 |
Very slight | – | – | – | – | – | – | – | – | 1 | – | – | ||
Slight | – | – | – | – | – | 1 | 1 | – | – | – | – | ||
0.5 mg/kg | None | – | – | – | – | 7 | 8 | 8 | 8 | 6 | 5 | 8 | |
Very slight | – | – | – | – | – | – | – | – | 2 | 2 | – | ||
Slight | – | – | – | – | 1 | – | – | – | – | 1 | – | ||
1.5 mg/kg | None | – | – | – | – | 8 | 6 | 6 | 5 | 3 | 2 | 4 | |
Very slight | – | – | – | – | – | 1 | 1 | – | 1 | 2 | 4 | ||
Slight | – | – | – | – | – | 1 | 1 | 3 | 4 | 4 | – | ||
2.5 mg/kg | None | – | – | – | – | 8 | 8 | 8 | 3 | 1 | 1 | 3 | |
Very slight | – | – | – | – | – | – | – | 4 | 2 | 1 | 3 | ||
Slight | – | – | – | – | – | – | – | 1 | 5 | 6 | 2 | ||
Day 364 | Control | None | – | – | – | – | – | – | – | – | – | – | 8 |
0.5 mg/kg | None | – | – | – | – | – | – | – | – | – | – | 8 | |
1.5 mg/kg | None | – | – | – | – | – | – | – | – | – | – | 3 | |
Very slight | – | – | – | – | – | – | – | – | – | – | 4 | ||
Slight | – | – | – | – | – | – | – | – | – | – | 1 | ||
2.5 mg/kg | None | – | – | – | – | – | – | – | – | – | – | 3 | |
Very slight | – | – | – | – | – | – | – | – | – | – | 3 | ||
Slight | – | – | – | – | – | – | – | – | – | – | 2 |