Laboratory and field studies to investigate the efficacy of a novel, orally administered combination product containing moxidectin, sarolaner and pyrantel for the prevention of heartworm disease (Dirofilaria immitis) in dogs

Table 1 Total worm counts, means and percent reduction relative to placebo for dogs treated orally with combination product tablets 30 days after experimental infection with Dirofilaria immitis (ZoeKY-2013, Laboratory Study 1)

	Treatment
	Placebo	Moxidectin/Sarolaner/Pyrantel combination product
Total worm counts for individual dogs	32	0
	32	0
	32	0
	36	0
	20	0
	37	0
	33	0
	27	0
Range	20–37	0–0
Arithmetic mean	31.1	0
% reduction	–	100
Geometric mean	30.7	0
% reduction	–	100
P-value	–	< 0.0001

ISSN: 1756-3305