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Table 2 Total worm counts, means and percent reduction relative to placebo for dogs treated orally with combination product, sarolaner-alone or moxidectin-alone tablets 30 days after experimental infection with Dirofilaria immitis (GCFL-01-2014, Laboratory Study 2)

From: Laboratory and field studies to investigate the efficacy of a novel, orally administered combination product containing moxidectin, sarolaner and pyrantel for the prevention of heartworm disease (Dirofilaria immitis) in dogs

 Treatment
PlaceboSarolanerMoxidectinMoxidectin/Sarolaner/Pyrantel combination product
Total worm counts for individual dogs393700
423300
443200
414000
393900
403800
403800
353700
Range35–4432–400–00–0
Arithmetic mean40.036.800
% Reduction8.1100100
Geometric mean39.936.700
% Reduction8.2100100
P-value vs placebo0.0026< 0.0001< 0.0001
P-value vs sarolaner< 0.0001< 0.0001
P-value vs moxidectin1.0