Fig. 5
From: Nanostructured lipid carriers of ivermectin as a novel drug delivery system in hydatidosis
a An expression of caspase-3 mRNA level in PSCs treated with PBS (negative control), PSCs treated with NLCs (negative control), PSCs treated with IVMs, and PSCs treated with NLCs-loaded IVM. Bar graph indicates the mean ± standard deviation. Caspase-3 mRNA expression was higher in both PSC treated with IVMs and NLCs-loaded IVM than the control groups (PBS, Mann–Whitney U-test: Z = − 2.80224, P = 0.005; NLCs, Mann–Whitney U-test: Z  = − 2.50672, P = 0.01). b Protoscolex DNA fragmentation after treatment with IVMs (Lane 1), PBS (Lane 2), NLCs-loaded IVM (Lane 3), NLCs (Lane 4) and a 100-bp DNA marker (Lane M)