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Table 2 Histological alterations in the livers of dogs with and without positive splenic aspirate culture

From: Assessment of histological liver alterations in dogs naturally infected with Leishmania infantum

Histological alteration

With positive splenic aspirate culture (N = 68)

Without positive splenic aspirate culture (N = 80)

n (%)

n (%)

Portal inflammation

67 (99)**

72 (90)

Intrasinusoidal granulomas

44 (65)

43 (54)

Kupffer cell hyperplasia

43 (63)

55 (69)

Kupffer cell hypertrophy

39 (57)

51 (64)

Portal granulomas

24 (35)***

6 (8)

Intrasinusoidal lymphocytosis

51 (75)

64 (80)

Congestion of sinusoids

8 (12)

13 (16)

Dilation of sinusoids

10 (15)

17 (21)

Intrasinusoidal aggregates

38 (56)

47 (59)

Perivascular inflammation

66 (97)

74 (93)

Hepatocyte steatosis

14 (21)

14 (18)

Ballooning of hepatocytes

20 (29)*

11 (14)

Hepatocyte necrosis

10 (15)

15 (19)

  1. * P < 0.05, ** P < 0.01, *** P < 0.005