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Table 2 Histological alterations in the livers of dogs with and without positive splenic aspirate culture

From: Assessment of histological liver alterations in dogs naturally infected with Leishmania infantum

Histological alterationWith positive splenic aspirate culture (N = 68)Without positive splenic aspirate culture (N = 80)
n (%)n (%)
Portal inflammation67 (99)**72 (90)
Intrasinusoidal granulomas44 (65)43 (54)
Kupffer cell hyperplasia43 (63)55 (69)
Kupffer cell hypertrophy39 (57)51 (64)
Portal granulomas24 (35)***6 (8)
Intrasinusoidal lymphocytosis51 (75)64 (80)
Congestion of sinusoids8 (12)13 (16)
Dilation of sinusoids10 (15)17 (21)
Intrasinusoidal aggregates38 (56)47 (59)
Perivascular inflammation66 (97)74 (93)
Hepatocyte steatosis14 (21)14 (18)
Ballooning of hepatocytes20 (29)*11 (14)
Hepatocyte necrosis10 (15)15 (19)
  1. P < 0.05, ** P < 0.01, *** P < 0.005