Table 3 Histological alterations in the livers of symptomatic dogs with positive Leishmania culture versus animals with other clinical classifications
From: Assessment of histological liver alterations in dogs naturally infected with Leishmania infantum
Histological alteration | Symptomatic with positive culture (N = 65) | Other classifications (N = 83) | OR (95% CI) | Adj. OR |
|---|---|---|---|---|
n (%) | n (%) | |||
Portal inflammation | 64 (98) | 75 (90) | 3.7 (1.99–6.9)** | 3.7** |
Intralobular granulomas | 42 (65) | 45 (54) | 1.55 (1.1–2.2)* | 1.59* |
Kupffer cell hyperplasia | 42 (65) | 56 (67) | 0.93 (0.6–1.4) | 1.2 |
Kupffer cell hypertrophy | 38 (58) | 52 (63) | 0.91 (0.6–1.3) | 1.13 |
Portal granulomas | 23 (35) | 7 (8) | 3.66 (1.8–7.3)** | 3.07** |
Intrasinusoidal lymphocytosis | 50 (77) | 65 (78) | 1.02 (0.7–1.5) | 1.37 |
Congestion of sinusoids | 14 (22) | 13 (16) | 0.83 (0.4–1.7) | 1.23 |
Dilation of sinusoids | 10 (15) | 17 (20) | 0.82 (0.4–1.5) | 0.7 |
Intrasinusoidal aggregates | 38 (58) | 47 (57) | 1.04 (0.7–1.5) | 1.16 |
Perivascular inflammation | 63 (97) | 77 (93) | 2.76 (1.6–4.8)** | 2.9** |
Hepatocyte steatosis | 14 (22) | 14 (17) | 1.16 (0.7–1.8) | 0.9 |
Ballooning of hepatocytes | 20 (31) | 11 (13) | 1.88 (1.2–2.9)** | 1.39 |
Hepatocyte necrosis | 10 (15) | 15 (18) | 0.74 (0.4–1.5) | 1.05 |