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Table 3 Histological alterations in the livers of symptomatic dogs with positive Leishmania culture versus animals with other clinical classifications

From: Assessment of histological liver alterations in dogs naturally infected with Leishmania infantum

Histological alterationSymptomatic with positive culture (N = 65)Other classifications (N = 83)OR (95% CI)Adj. OR
n (%)n (%)
Portal inflammation64 (98)75 (90)3.7 (1.99–6.9)**3.7**
Intralobular granulomas42 (65)45 (54)1.55 (1.1–2.2)*1.59*
Kupffer cell hyperplasia42 (65)56 (67)0.93 (0.6–1.4)1.2
Kupffer cell hypertrophy38 (58)52 (63)0.91 (0.6–1.3)1.13
Portal granulomas23 (35)7 (8)3.66 (1.8–7.3)**3.07**
Intrasinusoidal lymphocytosis50 (77)65 (78)1.02 (0.7–1.5)1.37
Congestion of sinusoids14 (22)13 (16)0.83 (0.4–1.7)1.23
Dilation of sinusoids10 (15)17 (20)0.82 (0.4–1.5)0.7
Intrasinusoidal aggregates38 (58)47 (57)1.04 (0.7–1.5)1.16
Perivascular inflammation63 (97)77 (93)2.76 (1.6–4.8)**2.9**
Hepatocyte steatosis14 (22)14 (17)1.16 (0.7–1.8)0.9
Ballooning of hepatocytes20 (31)11 (13)1.88 (1.2–2.9)**1.39
Hepatocyte necrosis10 (15)15 (18)0.74 (0.4–1.5)1.05
  1. Abbreviation: Adj. OR, odds ratio adjusted re: parasitic burden on the spleen
  2. P < 0.05, ** P < 0.01