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Table 5 Associations between histological alterations in the liver and biochemical parameters

From: Assessment of histological liver alterations in dogs naturally infected with Leishmania infantum

Histological changeASTALTAlbuminGlobulinRatio A/G
Medianp25–p75 (N)Medianp25–p75 (N)Medianp25–p75 (N)Medianp25–p75 (N)Medianp25–p75 (N)
Portal inflammation
 Absent3026–34 (n = 2)32.532–33 (n = 2)32.7–3.3 (n = 2)65.3–6.7 (n = 2)0.50.4–0.6 (n = 2)
 Discreet33.5**24.2–51.8 (n = 40)3727–43 (n = 40)2.852.4–3.2 (n = 40)7.456–8.8 (n = 40)0.340.3–0.5 (n = 40)
 Moderate45**28–54 (n = 17)4029–65.5 (n =17)2.62.1–3.4 (n = 17)7.86.5–9 (n = 17)0.350.3–0.5 (n = 17)
 Intense8370–112.5 (n = 4)5022–72.8 (n = 4)2.31.7–2.7 (n = 3)6.45.4–8.3 (n = 3)0.420.2–0.4 (n = 3)
Perivascular inflammation
 Absent3426–43 (n = 3)3227–33 (n = 3)3.3*2.7–3.5 (n = 3)5.35.1–6.7 (n = 3)0.620.4–0.7 (n = 3)
 Discreet34.524–54 (n = 34)3829–46 (n = 34)2.85**2.4–3.3 (n = 34)7.36.2–9 (n =34)0.360.3–0.5 (n = 34)
 Moderate4228.5–53 (n = 21)3127–43 (n = 21)2.7**2.4–3.4 (n = 21)7.86.9–9 (n = 21)0.330.3–0.5 (n = 21)
 Intense7048–105 (n = 5)7230–75 (n = 5)1.81.7–2.2 (n = 4)6.55.6–7.9 (n = 4)0.280.2–0.4 (n = 4)
Intrasinusoidal aggregates
 Absent4731–58 (n = 18)39.530–60 (n = 18)2.72.4–3.3 (n = 17)6.7**5.3–7.9 (n = 17)0.43*0.3–0.6 (n = 17)
 Discreet3825–53 (n = 21)3427.5–38.5 (n = 21)32.2–3.5 (n = 21)6.7**5.6–7.6 (n = 21)0.42**0.3–0.6 (n = 21)
 Moderate33.527–51 (n = 18)38.527–46 (n = 18)2.652.4–3.2 (n = 18)8.57.4–9.7 (n = 18)0.2950.3–0.4 (n = 18)
 Intense5121–74 (n = 6)4018.5–84 (n = 6)2.42.1–3 (n = 6)8.26.8–10.2 (n = 6)0.2650.2–0.4 (n = 6)
Intralobular granulomas
 Absent35**28.5–49.5 (n = 25)3426–42.5 (n = 25)2.72.05–3.2 (n = 25)7.16.1–8 (n = 25)0.340.3–0.5 (n = 25)
 Discreet38*24–61.5 (n = 21)3527–43 (n = 21)32.4–3.4 (n = 21)7.46.4–9.8 (n = 21)0.40.3–0.5 (n = 21)
 Moderate31.5**25–48.8 (n = 10)38.529.2–44.8 (n = 10)2.62.4–3.4 (n = 10)7.96.4–9 (n = 10)0.340.3–0.5 (n = 10)
 Intense7549–110 (n = 7)7236–82 (n = 7)32.2–3.7 (n = 6)85.4–9.5 (n = 6)0.380.3–0.55 (n = 6)
Portal granulomas
 Absent34**25–48 (n = 55)36*27–43 (n = 55)2.82.4–3.3 (n = 55)7.56.4–8.8 (n = 55)0.340.3–0.5 (n = 55)
 Discreet6851.8–97 (n = 4)40.530.5–47.5 (n = 4)32.5–3.45 (n = 4)6.95.6–7.7 (n = 4)0.440,3–0,6 (n = 4)
 Moderate6868–68 (n = 1)2020–20 (n = 1)2.32.3–2.3 (n = 1)5.45.4–5.4 (n = 1)0.430.4–0.4 (n = 1)
 Intense9075–120 (n = 3)7372–120 (n = 3)2.151.7–2.6 (n = 2)8.758.3–9.2 (n = 2)0.240.2–0.3 (n = 2)
  1. *P < 0.05, **P < 0.01