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Fig. 6 | Parasites & Vectors

Fig. 6

From: Soluble egg antigen of Schistosoma japonicum induces pyroptosis in hepatic stellate cells by modulating ROS production

Fig. 6

Proposed model of HSCs pyroptosis in SEA-induced schistosomiasis. SEA stimulates HSCs and induces the production of ROS, which leads to the activation of caspase-1. Caspase-1 activation contributes to the pyroptotic cell death and the release of DAMPs which terminally result in the formation of hepatic inflammatory microenvironment, subsequent promoting schistosomiasis. Abbreviations: SEA, soluble egg antigen; ROS, reactive oxygen species; HSCs, hepatic stellate cells; DAMPs, damage-associated molecular pattern

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