Skip to main content

Advertisement

Table 1 Highlighted (↑, upregulated; ↓, downregulated) compounds obtained from untargeted metabolomics of serum samples of gilthead sea bream inoculated with Enteromyxum leei. Non-infected (C) fish were compared with highly (R-H) or low/moderately (R-L/M) infected recipient (R) fish

From: Disruption of gut integrity and permeability contributes to enteritis in a fish-parasite model: a story told from serum metabolomics

Compound Biological process# Feature name Chromatography/ ionization mode Formula m/z (Da) R-H, % C R-L/M, % C Corrected P-value*
Isobutyryl carnitine ↑ 1 M232T96_RPPOS RP/+ C11H21NO4 232.2967 1615b 969c 6.78E−3
Pivaloylcarnitine ↑ 1 M246T150_RPPOS RP/+ C12H23NO4 245.3153 1128b 664c 5.72E−3
2-methylbutyroylcarnitine ↑ 1 M246T155_RPPOS RP/+ C12H23NO4 246.3233 955b 470c 1.42E−2
Myristoylcarnitine ↑ 1 M372T767_RPPOS RP/+ C21H41NO4 372.5625 303b 127a 3.37E−2
(c18:1)oylcarnitine ↓ 1 M426T788_RPPOS RP/+ C25H47NO4 426.3571 32b 36b 6.21E−03
Oxoadipic acid ↑ 2 M159T74_RPNEG RP/− C6H8O5 159.1168 4704b 8660c 1.63E−2
Leucinic acid ↑ 2 M131T254_RPNEG RP/− C6H12O3 131.1497 949b 632c 1.39E−2
γ -Glu-Val ↑ 2 M247T94_RPPOS RP/+ C10H18N2O5 247.2683 402b 202c 7.33E−3
γ-Glu-Ile ↑ 2 M261T171_RPPOS RP/+ C11H20N2O5 259.2790 343b 255b 2.60E−2
Creatine ↑ 3 M132T73_RPPOS RP/+ C4H9N3O2 132.1411 425b 245c 1.26E−2
Inosine ↓ 4 M267T72_RPNEG RP/− C10H12N4O 203.2205 94a 77b 2.37E−2
Guanosine ↓ 4 M282T73_RPNEG RP/− C10H13N5O5 282.2328 70a 58b 4.42E−2
LysoPC(20:4) ↓ 5 M544T874_RPPOS RP/+ C28H50NO7P 543.6729 67b 46b 6.13E−2
LysoPE(18:2) ↑ 5 M478T906_RPNEG RP/− C23H44NO7P 476.5638 199b 106a 1.31E−2
LysoPE(16:0) ↑ 5 M452T895_RPNEG RP/− C21H44NO7P 454.5583 259b 143b 4.05E−3
LysoPE(18:1) ↑ 5 M480T944_RPNEG RP/− C23H46NO7P 480.5855 185b 123a 2.14E−2
Biotin (vitamin B7) ↓ 6 M245T223_RPPOS RP/+ C10H16N2O3S 245.3186 28b 66c 2.69E−2
Pantothenic acid (vitamin B5)↓ 6 M220T115_RPPOS RP/+ C9H17NO5 220.2429 27b 71c 3.56E−2
Delta-valerolactam ↓ 6 M100T100_RPPOS RP/+ C5H9NO 100.1390 16b 38c 6.72E−3
p-aminobenzoic acid (PABA) ↑ 6 M138T94_RPPOS RP/+ C7H7NO2 137.0474 177b 215b 1.44E−2
  1. #1, fatty acid oxidation; 2, amino acid catabolism; 3, energy homeostasis; 4, nucleoside metabolism; 5, lysophospholid metabolism; 6, vitamins and polyphenols metabolism
  2. *Benjamini-Hochberg multiple testing correction
  3. Note: Superscript letters indicate statistically significant differences, using letter a for C group