Table 1 Highlighted (↑, upregulated; ↓, downregulated) compounds obtained from untargeted metabolomics of serum samples of gilthead sea bream inoculated with Enteromyxum leei. Non-infected (C) fish were compared with highly (R-H) or low/moderately (R-L/M) infected recipient (R) fish

Isobutyryl carnitine ↑

1

M232T96_RPPOS

RP/+

C₁₁H₂₁NO₄

232.2967

1615^b

969^c

6.78E⁻³

Pivaloylcarnitine ↑

1

M246T150_RPPOS

RP/+

C₁₂H₂₃NO₄

245.3153

1128^b

664^c

5.72E⁻³

2-methylbutyroylcarnitine ↑

1

M246T155_RPPOS

RP/+

C₁₂H₂₃NO₄

246.3233

955^b

470^c

1.42E⁻²

Myristoylcarnitine ↑

1

M372T767_RPPOS

RP/+

C₂₁H₄₁NO₄

372.5625

303^b

127^a

3.37E⁻²

(c18:1)oylcarnitine ↓

1

M426T788_RPPOS

RP/+

C₂₅H₄₇NO₄

426.3571

32^b

36^b

6.21E⁻⁰³

Oxoadipic acid ↑

2

M159T74_RPNEG

RP/−

C₆H₈O₅

159.1168

4704^b

8660^c

1.63E⁻²

Leucinic acid ↑

2

M131T254_RPNEG

RP/−

C₆H₁₂O₃

131.1497

949^b

632^c

1.39E⁻²

γ -Glu-Val ↑

2

M247T94_RPPOS

RP/+

C₁₀H₁₈N₂O₅

247.2683

402^b

202^c

7.33E⁻³

γ-Glu-Ile ↑

2

M261T171_RPPOS

RP/+

C₁₁H₂₀N₂O₅

259.2790

343^b

255^b

2.60E⁻²

Creatine ↑

3

M132T73_RPPOS

RP/+

C₄H₉N₃O₂

132.1411

425^b

245^c

1.26E⁻²

Inosine ↓

4

M267T72_RPNEG

RP/−

C₁₀H₁₂N₄O

203.2205

94^a

77^b

2.37E⁻²

Guanosine ↓

4

M282T73_RPNEG

RP/−

C₁₀H₁₃N₅O₅

282.2328

70^a

58^b

4.42E⁻²

LysoPC(20:4) ↓

5

M544T874_RPPOS

RP/+

C₂₈H₅₀NO₇P

543.6729

67^b

46^b

6.13E⁻²

LysoPE(18:2) ↑

5

M478T906_RPNEG

RP/−

C₂₃H₄₄NO₇P

476.5638

199^b

106^a

1.31E⁻²

LysoPE(16:0) ↑

5

M452T895_RPNEG

RP/−

C₂₁H₄₄NO₇P

454.5583

259^b

143^b

4.05E⁻³

LysoPE(18:1) ↑

5

M480T944_RPNEG

RP/−

C₂₃H₄₆NO₇P

480.5855

185^b

123^a

2.14E⁻²

Biotin (vitamin B7) ↓

6

M245T223_RPPOS

RP/+

C₁₀H₁₆N₂O₃S

245.3186

28^b

66^c

2.69E⁻²

Pantothenic acid (vitamin B5)↓

6

M220T115_RPPOS

RP/+

C₉H₁₇NO₅

220.2429

27^b

71^c

3.56E⁻²

Delta-valerolactam ↓

6

M100T100_RPPOS

RP/+

C₅H₉NO

100.1390

16^b

38^c

6.72E⁻³

p-aminobenzoic acid (PABA) ↑

6

M138T94_RPPOS

RP/+

C₇H₇NO₂

137.0474

177^b

215^b

1.44E⁻²