TY - STD TI - WHO. Crossing the Billion. Preventive chemotherapy for neglected tropical diseases. Geneva: World Health Organization; 2017. http://www.who.int/neglected_diseases/resources/9789240696471/en/. Accessed 5 Sept 2017. UR - http://www.who.int/neglected_diseases/resources/9789240696471/en/ ID - ref1 ER - TY - JOUR AU - Caffrey, C. R. PY - 2007 DA - 2007// TI - Chemotherapy of schistosomiasis: present and future JO - Curr Opin Chem Biol VL - 11 UR - https://doi.org/10.1016/j.cbpa.2007.05.031 DO - 10.1016/j.cbpa.2007.05.031 ID - Caffrey2007 ER - TY - JOUR AU - McManus, D. P. AU - Dunne, D. W. AU - Sacko, M. AU - Utzinger, J. AU - Vennervald, B. J. AU - Zhou, X. -. N. PY - 2018 DA - 2018// TI - Schistosomiasis JO - Nat Rev Dis Primer. VL - 4 UR - https://doi.org/10.1038/s41572-018-0013-8 DO - 10.1038/s41572-018-0013-8 ID - McManus2018 ER - TY - JOUR AU - Caffrey, C. R. PY - 2015 DA - 2015// TI - Schistosomiasis and its treatment JO - Future Med Chem. VL - 7 UR - https://doi.org/10.4155/fmc.15.27 DO - 10.4155/fmc.15.27 ID - Caffrey2015 ER - TY - JOUR AU - Wolfe, A. R. AU - Neitz, R. J. AU - Burlingame, M. AU - Suzuki, B. M. AU - Lim, K. C. AU - Scheideler, M. PY - 2018 DA - 2018// TI - TPT sulfonate, a single, oral dose schistosomicidal prodrug: in vivo efficacy, disposition and metabolic profiling JO - Int J Parasitol Drugs Drug Resist VL - 8 UR - https://doi.org/10.1016/j.ijpddr.2018.10.004 DO - 10.1016/j.ijpddr.2018.10.004 ID - Wolfe2018 ER - TY - JOUR AU - Abdulla, M. -. H. AU - Ruelas, D. S. AU - Wolff, B. AU - Snedecor, J. AU - Lim, K. -. C. AU - Xu, F. PY - 2009 DA - 2009// TI - Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening JO - PLoS Negl Trop Dis VL - 3 UR - https://doi.org/10.1371/journal.pntd.0000478 DO - 10.1371/journal.pntd.0000478 ID - Abdulla2009 ER - TY - JOUR AU - Tekwu, E. M. AU - Anyan, W. K. AU - Boamah, D. AU - Baffour-Awuah, K. O. AU - Keyetat Tekwu, S. AU - Penlap Beng, V. PY - 2016 DA - 2016// TI - Mechanically produced schistosomula as a higher-throughput tools for phenotypic pre-screening in drug sensitivity assays: current research and future trends JO - Biomark Res. VL - 4 UR - https://doi.org/10.1186/s40364-016-0075-2 DO - 10.1186/s40364-016-0075-2 ID - Tekwu2016 ER - TY - JOUR AU - Lombardo, F. C. AU - Pasche, V. AU - Panic, G. AU - Endriss, Y. AU - Keiser, J. PY - 2019 DA - 2019// TI - Life cycle maintenance and drug-sensitivity assays for early drug discovery in Schistosoma mansoni JO - Nat Protoc. VL - 14 UR - https://doi.org/10.1038/s41596-018-0101-y DO - 10.1038/s41596-018-0101-y ID - Lombardo2019 ER - TY - JOUR AU - Asarnow, D. AU - Rojo-Arreola, L. AU - Suzuki, B. M. AU - Caffrey, C. R. AU - Singh, R. PY - 2015 DA - 2015// TI - The QDREC web server: determining dose-response characteristics of complex macroparasites in phenotypic drug screens JO - Bioinformatics. VL - 31 UR - https://doi.org/10.1093/bioinformatics/btu831 DO - 10.1093/bioinformatics/btu831 ID - Asarnow2015 ER - TY - JOUR AU - Panic, G. AU - Flores, D. AU - Ingram-Sieber, K. AU - Keiser, J. PY - 2015 DA - 2015// TI - Fluorescence/luminescence-based markers for the assessment of Schistosoma mansoni schistosomula drug assays JO - Parasites Vectors. VL - 8 UR - https://doi.org/10.1186/s13071-015-1233-3 DO - 10.1186/s13071-015-1233-3 ID - Panic2015 ER - TY - JOUR AU - Paveley, R. A. AU - Mansour, N. R. AU - Hallyburton, I. AU - Bleicher, L. S. AU - Benn, A. E. AU - Mikic, I. PY - 2012 DA - 2012// TI - Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases JO - PLoS Negl Trop Dis VL - 6 UR - https://doi.org/10.1371/journal.pntd.0001762 DO - 10.1371/journal.pntd.0001762 ID - Paveley2012 ER - TY - JOUR AU - Voorhis, W. C. V. AU - Adams, J. H. AU - Adelfio, R. AU - Ahyong, V. AU - Akabas, M. H. AU - Alano, P. PY - 2016 DA - 2016// TI - Open source drug discovery with the Malaria Box compound collection for neglected diseases and beyond JO - PLOS Pathog VL - 12 UR - https://doi.org/10.1371/journal.ppat.1005763 DO - 10.1371/journal.ppat.1005763 ID - Voorhis2016 ER - TY - JOUR AU - Duffy, S. AU - Sykes, M. L. AU - Jones, A. J. AU - Shelper, T. B. AU - Simpson, M. AU - Lang, R. PY - 2017 DA - 2017// TI - Screening the Medicines for Malaria Venture Pathogen Box across multiple pathogens reclassifies starting points for open-source drug discovery JO - Antimicrob Agents Chemother. VL - 61 UR - https://doi.org/10.1128/AAC.00379-17 DO - 10.1128/AAC.00379-17 ID - Duffy2017 ER - TY - JOUR AU - Ingram-Sieber, K. AU - Cowan, N. AU - Panic, G. AU - Vargas, M. AU - Mansour, N. R. AU - Bickle, Q. D. PY - 2014 DA - 2014// TI - Orally active antischistosomal early leads identified from the open access Malaria Box JO - PLoS Negl Trop Dis. VL - 8 UR - https://doi.org/10.1371/journal.pntd.0002610 DO - 10.1371/journal.pntd.0002610 ID - Ingram-Sieber2014 ER - TY - JOUR AU - Pasche, V. AU - Laleu, B. AU - Keiser, J. PY - 2019 DA - 2019// TI - Early antischistosomal leads identified from in vitro and in vivo screening of the medicines for Malaria Venture Pathogen Box JO - ACS Infect Dis. VL - 5 UR - https://doi.org/10.1021/acsinfecdis.8b00220 DO - 10.1021/acsinfecdis.8b00220 ID - Pasche2019 ER - TY - JOUR AU - Pasche, V. AU - Laleu, B. AU - Keiser, J. PY - 2018 DA - 2018// TI - Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni JO - Parasites Vectors VL - 11 UR - https://doi.org/10.1186/s13071-018-2855-z DO - 10.1186/s13071-018-2855-z ID - Pasche2018 ER - TY - JOUR AU - Stefanic, S. AU - Dvorak, J. AU - Horn, M. AU - Braschi, S. AU - Sojka, D. AU - Ruelas, D. S. PY - 2010 DA - 2010// TI - RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening JO - PLoS Negl Trop Dis VL - 4 UR - https://doi.org/10.1371/journal.pntd.0000850 DO - 10.1371/journal.pntd.0000850 ID - Stefanic2010 ER - TY - JOUR AU - Colley, D. G. AU - Wikel, S. K. PY - 1974 DA - 1974// TI - Schistosoma mansoni: simplified method for the production of schistosomules JO - Exp Parasitol. VL - 35 UR - https://doi.org/10.1016/0014-4894(74)90005-8 DO - 10.1016/0014-4894(74)90005-8 ID - Colley1974 ER - TY - JOUR AU - Basch, P. PY - 1981 DA - 1981// TI - Cultivation of Schistosoma mansoni in vitro. 1. Establishment of cultures from cercariae and development until pairing JO - J Parasitol. VL - 67 UR - https://doi.org/10.2307/3280632 DO - 10.2307/3280632 ID - Basch1981 ER - TY - JOUR AU - Long, T. AU - Neitz, R. J. AU - Beasley, R. AU - Kalyanaraman, C. AU - Suzuki, B. M. AU - Jacobson, M. P. PY - 2016 DA - 2016// TI - Structure-bioactivity relationship for benzimidazole thiophene inhibitors of Polo-like kinase 1 (PLK1), a potential drug target in Schistosoma mansoni JO - PLoS Negl Trop Dis. VL - 10 UR - https://doi.org/10.1371/journal.pntd.0004356 DO - 10.1371/journal.pntd.0004356 ID - Long2016 ER - TY - JOUR AU - Long, T. AU - Rojo-Arreola, L. AU - Shi, D. AU - El-Sakkary, N. AU - Jarnagin, K. AU - Rock, F. PY - 2017 DA - 2017// TI - Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target JO - PLoS Negl Trop Dis. VL - 11 UR - https://doi.org/10.1371/journal.pntd.0005680 DO - 10.1371/journal.pntd.0005680 ID - Long2017 ER - TY - JOUR AU - Rojo-Arreola, L. AU - Long, T. AU - Asarnow, D. AU - Suzuki, B. M. AU - Singh, R. AU - Caffrey, C. R. PY - 2014 DA - 2014// TI - Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis JO - PLoS ONE. VL - 9 UR - https://doi.org/10.1371/journal.pone.0087594 DO - 10.1371/journal.pone.0087594 ID - Rojo-Arreola2014 ER - TY - JOUR AU - Glaser, J. AU - Schurigt, U. AU - Suzuki, B. M. AU - Caffrey, C. R. AU - Holzgrabe, U. PY - 2015 DA - 2015// TI - Anti-schistosomal activity of cinnamic acid esters: eugenyl and thymyl cinnamate induce cytoplasmic vacuoles and death in schistosomula of Schistosoma mansoni JO - Molecules VL - 20 UR - https://doi.org/10.3390/molecules200610873 DO - 10.3390/molecules200610873 ID - Glaser2015 ER - TY - JOUR AU - Weeks, J. C. AU - Roberts, W. M. AU - Leasure, C. AU - Suzuki, B. M. AU - Robinson, K. J. AU - Currey, H. PY - 2018 DA - 2018// TI - Sertraline, paroxetine, and chlorpromazine are rapidly acting anthelmintic drugs capable of clinical repurposing JO - Sci Rep. VL - 8 UR - https://doi.org/10.1038/s41598-017-18457-w DO - 10.1038/s41598-017-18457-w ID - Weeks2018 ER - TY - JOUR AU - Milligan, J. N. AU - Jolly, E. R. PY - 2011 DA - 2011// TI - Cercarial transformation and in vitro cultivation of Schistosoma mansoni schistosomules JO - J Vis Exp. VL - 54 ID - Milligan2011 ER - TY - JOUR AU - Mäser, P. AU - Grether-Bühler, Y. AU - Kaminsky, R. AU - Brun, R. PY - 2002 DA - 2002// TI - An anti-contamination cocktail for the in vitro isolation and cultivation of parasitic protozoa JO - Parasitol Res. VL - 88 UR - https://doi.org/10.1007/s00436-001-0511-5 DO - 10.1007/s00436-001-0511-5 ID - Mäser2002 ER - TY - JOUR AU - Ramirez, B. AU - Bickle, Q. AU - Yousif, F. AU - Fakorede, F. AU - Mouries, M. -. A. AU - Nwaka, S. PY - 2007 DA - 2007// TI - Schistosomes: challenges in compound screening JO - Expert Opin Drug Discov. VL - 2 UR - https://doi.org/10.1517/17460441.2.S1.S53 DO - 10.1517/17460441.2.S1.S53 ID - Ramirez2007 ER - TY - JOUR AU - Aguiar, P. H. N. AU - Fernandes, N. M. G. S. AU - Zani, C. L. AU - Mourão, M. M. PY - 2017 DA - 2017// TI - A high-throughput colorimetric assay for detection of Schistosoma mansoni viability based on the tetrazolium salt XTT JO - Parasites Vectors. VL - 10 UR - https://doi.org/10.1186/s13071-017-2240-3 DO - 10.1186/s13071-017-2240-3 ID - Aguiar2017 ER - TY - JOUR AU - Scudiero, D. A. AU - Shoemaker, R. H. AU - Paull, K. D. AU - Monks, A. AU - Tierney, S. AU - Nofziger, T. H. PY - 1988 DA - 1988// TI - Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines JO - Cancer Res. VL - 48 ID - Scudiero1988 ER - TY - JOUR AU - Abagyan, R. AU - Totrov, M. AU - Kuznetsov, D. PY - 1994 DA - 1994// TI - ICM - a new method for protein modeling and design: applications to docking and structure prediction from the distorted native conformation JO - J Comput Chem. VL - 15 UR - https://doi.org/10.1002/jcc.540150503 DO - 10.1002/jcc.540150503 ID - Abagyan1994 ER - TY - STD TI - Wickham H. ggplot2: elegant graphics for data analysis. New York: Springer; 2016. https://ggplot2.tidyverse.org. Accessed 2 Aug 2019. UR - https://ggplot2.tidyverse.org ID - ref31 ER - TY - JOUR AU - Lalli, C. AU - Guidi, A. AU - Gennari, N. AU - Altamura, S. AU - Bresciani, A. AU - Ruberti, G. PY - 2015 DA - 2015// TI - Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni JO - PLoS Negl Trop Dis. VL - 9 UR - https://doi.org/10.1371/journal.pntd.0003484 DO - 10.1371/journal.pntd.0003484 ID - Lalli2015 ER - TY - JOUR AU - Peak, E. AU - Chalmers, I. W. AU - Hoffmann, K. F. PY - 2010 DA - 2010// TI - Development and validation of a quantitative, high-throughput, fluorescent-based bioassay to detect Schistosoma viability JO - PLoS Negl Trop Dis. VL - 4 UR - https://doi.org/10.1371/journal.pntd.0000759 DO - 10.1371/journal.pntd.0000759 ID - Peak2010 ER - TY - JOUR AU - Rinaldi, G. AU - Loukas, A. AU - Brindley, P. J. AU - Irelan, J. T. AU - Smout, M. J. PY - 2015 DA - 2015// TI - Viability of developmental stages of Schistosoma mansoni quantified with xCELLigence worm real-time motility assay (xWORM) JO - Int J Parasitol Drugs Drug Resist. VL - 5 UR - https://doi.org/10.1016/j.ijpddr.2015.07.002 DO - 10.1016/j.ijpddr.2015.07.002 ID - Rinaldi2015 ER - TY - JOUR AU - Fonseca, N. C. AU - Cruz, L. F. AU - Silva Villela, F. AU - Nascimento Pereira, G. A. AU - Siqueira-Neto, J. L. AU - Kellar, D. PY - 2015 DA - 2015// TI - Synthesis of a sugar-based thiosemicarbazone series and structure–activity relationship versus the parasite cysteine proteases Rhodesain, Cruzain, and Schistosoma mansoni Cathepsin B1 JO - Antimicrob Agents Chemother. VL - 59 UR - https://doi.org/10.1128/AAC.04601-14 DO - 10.1128/AAC.04601-14 ID - Fonseca2015 ER - TY - JOUR AU - Panic, G. AU - Vargas, M. AU - Scandale, I. AU - Keiser, J. PY - 2015 DA - 2015// TI - Activity profile of an FDA-approved compound library against Schistosoma mansoni JO - PLoS Negl Trop Dis. VL - 9 UR - https://doi.org/10.1371/journal.pntd.0003962 DO - 10.1371/journal.pntd.0003962 ID - Panic2015 ER - TY - JOUR AU - Keiser, J. AU - Chollet, J. AU - Xiao, S. -. H. AU - Mei, J. -. Y. AU - Jiao, P. -. Y. AU - Utzinger, J. PY - 2009 DA - 2009// TI - Mefloquine—an aminoalcohol with promising antischistosomal properties in mice JO - PLoS Negl Trop Dis. VL - 3 UR - https://doi.org/10.1371/journal.pntd.0000350 DO - 10.1371/journal.pntd.0000350 ID - Keiser2009 ER - TY - JOUR AU - Alger, H. M. AU - Williams, D. L. PY - 2002 DA - 2002// TI - The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase JO - Mol Biochem Parasitol. VL - 121 UR - https://doi.org/10.1016/S0166-6851(02)00031-2 DO - 10.1016/S0166-6851(02)00031-2 ID - Alger2002 ER - TY - JOUR AU - Angelucci, F. AU - Sayed, A. A. AU - Williams, D. L. AU - Boumis, G. AU - Brunori, M. AU - Dimastrogiovanni, D. PY - 2009 DA - 2009// TI - Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin structural and kinetic aspects JO - J Biol Chem. VL - 284 UR - https://doi.org/10.1074/jbc.M109.020701 DO - 10.1074/jbc.M109.020701 ID - Angelucci2009 ER - TY - JOUR AU - Lee, H. AU - Moody-Davis, A. AU - Saha, U. AU - Suzuki, B. M. AU - Asarnow, D. AU - Chen, S. PY - 2012 DA - 2012// TI - Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis JO - BMC Genomics. VL - 13 UR - https://doi.org/10.1186/1471-2164-13-S1-S4 DO - 10.1186/1471-2164-13-S1-S4 ID - Lee2012 ER - TY - STD TI - Singh R, Pittas M, Heskia I, Xu F, McKerrow J, Caffrey CR. Automated image-based phenotypic screening for high-throughput drug discovery. In: 2009 22nd IEEE international symposium on computer-based medical systems; 2009. p. 1–8. ID - ref41 ER - TY - JOUR AU - Bertão, H. G. AU - Silva, R. A. R. AU - Padilha, R. J. R. AU - Azevedo Albuquerque, M. C. P. AU - Rádis-Baptista, G. PY - 2012 DA - 2012// TI - Ultrastructural analysis of miltefosine-induced surface membrane damage in adult Schistosoma mansoni BH strain worms JO - Parasitol Res. VL - 110 UR - https://doi.org/10.1007/s00436-011-2786-5 DO - 10.1007/s00436-011-2786-5 ID - Bertão2012 ER - TY - JOUR AU - Eissa, M. M. AU - El-Moslemany, R. M. AU - Ramadan, A. A. AU - Amer, E. I. AU - El-Azzouni, M. Z. AU - El-Khordagui, L. K. PY - 2015 DA - 2015// TI - Miltefosine lipid nanocapsules for single dose oral treatment of schistosomiasis mansoni: a preclinical study JO - PLoS ONE VL - 10 UR - https://doi.org/10.1371/journal.pone.0141788 DO - 10.1371/journal.pone.0141788 ID - Eissa2015 ER - TY - JOUR AU - Eissa, M. M. AU - El-Azzouni, M. Z. AU - Amer, E. I. AU - Baddour, N. M. PY - 2011 DA - 2011// TI - Miltefosine, a promising novel agent for schistosomiasis mansoni JO - Int J Parasitol. VL - 41 UR - https://doi.org/10.1016/j.ijpara.2010.09.010 DO - 10.1016/j.ijpara.2010.09.010 ID - Eissa2011 ER - TY - JOUR AU - El-Faham, M. H. AU - Eissa, M. M. AU - Igetei, J. E. AU - Amer, E. I. AU - Liddell, S. AU - El-Azzouni, M. Z. PY - 2017 DA - 2017// TI - Treatment of Schistosoma mansoni with miltefosine in vitro enhances serological recognition of defined worm surface antigens JO - PLoS Negl Trop Dis. VL - 11 UR - https://doi.org/10.1371/journal.pntd.0005853 DO - 10.1371/journal.pntd.0005853 ID - El-Faham2017 ER - TY - JOUR AU - Couto, F. F. B. AU - Coelho, P. M. Z. AU - Araujo, N. AU - Kusel, J. R. AU - Katz, N. AU - Mattos, A. C. A. PY - 2010 DA - 2010// TI - Use of fluorescent probes as a useful tool to identify resistant Schistosoma mansoni isolates to praziquantel JO - Parasitology. VL - 137 UR - https://doi.org/10.1017/S003118201000065X DO - 10.1017/S003118201000065X ID - Couto2010 ER -