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Table 1 Degree of concordance in the number of actives and non-actives identified in the Pathogen Box between the UCSD (U), Swiss TPH (S) and FIOCRUZ (F) assays

From: Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery

Time (h)/Comparison

U vs S

U vs F

S vs F

U vs S vs F

24

87 (349)

na

na

na

48

87 (348)

na

na

na

72

87 (347)

83 (331)

78 (312)

74 (295)

  1. Notes: For the times indicated, the percentage (in bold) and number of compounds (in parentheses) that were identified as active or non-active between the institutions are indicated. Comparisons between UCSD and the Swiss TPH were run on a daily basis, whereas comparisons across all three groups were possible at the 72-h time point when the XTT assay (FIOCRUZ) was completed and the data analyzed
  2. Abbreviation: na, not applicable