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Table 2 Actives among the three assays for 13 compounds that had been designated earlier as ‘schistosomiasis active’ by the MMV

From: Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery

  UCSD Swiss TPH FIOCRUZ (mean ± SD)
MMV ID/Time point (h) 24 48 72 24 48 72 72
MMV688761 4 4 4 1.00 1.00 1.00 a  8.0 ± 2.5
MMV688763 4 4 4 1.00 1.00 1.00 a  5.8 ± 4.9
MMV688762 4 4 4 1.00 1.00 1.00 a  3.4 ± 3.7
MMV688768 3 4 4 1.00 1.00 1.00 a 6.4 ± 3.3
MMV688178 0 0 2 0.60 1.00 1.00 a 3.1 ± 8.5
MMV676382 4 4 4 0.45 0.68 0.94 a 61.7 ± 11.2
MMV688270 2 4 4 0.05 0.00 0.11a 39.0 ± 24.6
MMV688766 0 0 0 0.15 0.17 0.19 0.1 ± 0.4
MMV688313 0 2 0 0.10 0.17 0.28a 14.7 ± 1.7
MMV688771 1 2 0 0.05 0.10 0.16 62.2 ± 7.1
MMV676536 0 0 0 0.10 0.14 0.11a 75.5 ± 36.1
MMV688552 0 0 0 0.15 0.17 0.31 117.5 ± 14.6
MMV1198433 0 0 0 0.10 0.06 0.00 86.0 ± 19.9
  1. aCompounds that the Swiss TPH had previously determined as ‘schistosomiasis active’ vs schistosomula at 72 h during the assembly of the Pathogen Box. Active compounds are delineated in bold typeface