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Table 2 Actives among the three assays for 13 compounds that had been designated earlier as ‘schistosomiasis active’ by the MMV

From: Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery

 

UCSD

Swiss TPH

FIOCRUZ (mean ± SD)

MMV ID/Time point (h)

24

48

72

24

48

72

72

MMV688761

4

4

4

1.00

1.00

1.00 a

 8.0 ± 2.5

MMV688763

4

4

4

1.00

1.00

1.00 a

 5.8 ± 4.9

MMV688762

4

4

4

1.00

1.00

1.00 a

 3.4 ± 3.7

MMV688768

3

4

4

1.00

1.00

1.00 a

6.4 ± 3.3

MMV688178

0

0

2

0.60

1.00

1.00 a

3.1 ± 8.5

MMV676382

4

4

4

0.45

0.68

0.94 a

61.7 ± 11.2

MMV688270

2

4

4

0.05

0.00

0.11a

39.0 ± 24.6

MMV688766

0

0

0

0.15

0.17

0.19

0.1 ± 0.4

MMV688313

0

2

0

0.10

0.17

0.28a

14.7 ± 1.7

MMV688771

1

2

0

0.05

0.10

0.16

62.2 ± 7.1

MMV676536

0

0

0

0.10

0.14

0.11a

75.5 ± 36.1

MMV688552

0

0

0

0.15

0.17

0.31

117.5 ± 14.6

MMV1198433

0

0

0

0.10

0.06

0.00

86.0 ± 19.9

  1. aCompounds that the Swiss TPH had previously determined as ‘schistosomiasis active’ vs schistosomula at 72 h during the assembly of the Pathogen Box. Active compounds are delineated in bold typeface