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Table 3 Most prevalent drug resistant mutations in Plasmodium falciparum reported during recent years across Cameroon

From: Review of malaria situation in Cameroon: technical viewpoint on challenges and prospects for disease elimination

Gene Drugs affected by gene mutations Mutations detected in Cameroon Sites reporting drug resistance References
pfcrt CQ, AQ, LM K76T, M74I, N75E, K76 T, Q271K, I356K Mutengene, Ebolowa, Yaoundé, Bertoua, Douala, Kyé-Ossi, Ngaoundéré, Garoua [7, 17, 20, 147,148,149]
pfdhfr SP N511, C59R, S108N Yaoundé, Mont-Cameroon, Ngaoundéré, Garoua [17, 20, 147,148,149]
pfdhps SP K142N, I431V, S436A, A581G, A613S, K540E, A437G Yaoundé, Mont-Cameroon, Mutengene, Garoua [17, 20, 147, 149]
pfmdr-1 AQ, CQ, LM, MQ N86Y, Y184F, D1246Y Mutengene, Yaoundé, Garoua [17, 20, 149]
pfkelch13 Artemisinine K189Ta Mont-Cameroon [17]
  1. aThis mutation does not confer resistance to artemisinine
  2. Abbreviations: pfdhfr, P. falciparum dihydrofolate reductase; pfdhps, P. falciparum dihydropteroate synthase; pfcrt, P. falciparum chloroquine resistance transporter; pfmdr-1, P. falciparum multidrug resistance transporter 1; CQ, chloroquine; AQ, amodiaquine; LM, lumefantrine; SP, sulfadoxine-pyrimethamine; MQ, mefloquine