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Fig. 1 | Parasites & Vectors

Fig. 1

From: In silico selection of functionally important proteins from the mialome of Ornithodoros erraticus ticks and assessment of their protective efficacy as vaccine targets

Fig. 1

a Neighbour-joining analysis of the phylogenetic relationship of tick chitinases belonging to the glycoside hydrolase-18 (GH-18) family. OeCHI, Ornithodoros erraticus chitinase (red dot). Uniprot entry names are shown for the other sequences: AMBAM, Amblyomma americanum; IXORI, Ixodes ricinus; IXOSC, I. scapularis; ORNER, Ornithodoros erraticus; ORNMO, O. moubata; ORNTU, O. turicata; RHIPU, Rhipicephalus pulchellus; RHISA, R. sanguineus; RHIZA, R. zambeziensis. The Homo sapiens GH-18 chitobiase (Uniprot: Q01459) was included as outgroup reference. Evolutionary distances were computed using the Poisson correction method. Branch support values (10,000 bootstraps) for the nodes are indicated. b Linear B-cell epitope predictions for OeTSPs. The sequence of the protein is represented in triplicate showing the ABCpred (yelow), BCEpred (blue) and BepiPred-2.0 (green) predictions. The amino acids in epitopes predicted by at least two algorithms are highlighted in boxes. The signal peptide and transmembrane domain are depicted in red. The alanine 35 and asparagine 398 at the starting and end point of the GH-18 catalytic domain, respectively, and the active site FDGIALGWCKP are highlighted in bold red

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