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Table 4 Partial of upregulated DEGs in the high throughput sequencing data

From: Transcriptomic analysis of reproductive damage in the epididymis of male Kunming mice induced by chronic infection of Toxoplasma gondii PRU strain

Symbol Name log2(FC) Function
Iigp1 Interferon-inducible GTPase 1 6.5608 Required for disruption of the parasitophorous vacuole formed following T. gondii infection and subsequent killing of the parasite
Klrb1c Killer cell lectin-like receptor subfamily B member 1C 6.17868 Plays a stimulatory role on natural killer (NK) cells cytotoxicity, activation by cross-linking of the receptor induces Ca2+ mobilization and interferon-gamma production
Tgtp1 T cell-specific GTPase 1 5.61362 Involved in innate cell-autonomous resistance to intracellular pathogens, such as T. gondii
Tnfsf10 Tumor necrosis factor (ligand) superfamily, member 10 1.53097 Involved in male gonad development and regulation of the apoptotic process
Spata18 Spermatogenesis associated 18 1.29567 A key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage
Pgk2 Phosphoglycerate kinase 2 1.11099 Essential for sperm motility and male fertility but is not required for the completion of spermatogenesis
Piwil2 Piwi-like RNA-mediated gene silencing 2 1.1907 Essential role in meiotic differentiation of spermatocytes and self-renewal of spermatogonial stem cells