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Table 1 The chemical nomenclature, class, empirical formula, molar mass and solvent of ion transport inhibitors tested against A. castellanii

From: Novel insights into the potential role of ion transport in sensory perception in Acanthamoeba

CompoundChemical compositiona (if applicable)ClassEmpirical formulaMolar massSolvent and solubility
Gadolunium (III) chloride anhydrous Cation channel inhibitorGdCl3263.61Water
Strontium chloride anhydrous Calcium channel inhibitorSrCl2158.52Ethanol
CLP257(5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolonePotassium chloride cotransporterC14H14FN3O2S307.34DMSO 20 mg/ml
Tenatoprazole(RS)-3-Methoxy-8-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methylsulfinyl]-2,7,9-triazabicyclo[4.3.0]nona-2,4,8,10-tetraeneProton pump inhibitorC16H18N4O3S346.40DMSO 5 mg/ml
PF-03716556PF-03716556, [N-(2-Hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide]Acid pump inhibitorC22H26N4O3394.47DMSO ≥10 mg/ml
3′,4′-dichlorobenzamil hydrochlorideL-594,881Sodium–calcium exchanger inhibitorC13H12N7OCl3
HCl
425.10DMSO 30 mg/ml
Stevioside hydrate(4α-13-[(2-O-β-d-Glucopyranosyl-β-d-glucopyranosyl)oxy]kaur-16-en-18-oic acid β-d-glucopyranosyl esterPotassium channelC38H60O18
xH2O
804.87 (anhydrous basis)DMSO 25 mg/ml
CariporideHOE-642, N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)-benzamide, N-(Diaminomethylene)-4-isopropyl-3-(methylsulfonyl)benzamideSodium–hydrogen exchanger inhibitorC12H17N3O3S283.35DMSO 20 mg/ml
Lanthanum oxide Potassium channelLa2O3325.808Dilute nitric acid
  1. aIf applicable