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Fig. 5 | Parasites & Vectors

Fig. 5

From: Tim-3 signaling blockade with α-lactose induces compensatory TIGIT expression in Plasmodium berghei ANKA-infected mice

Fig. 5

Spleen index, survival rate, and the histopathology of lungs and spleens in P. berghei-infected mice with or without α-lactose treatment. a At 15 days p.i., mice were sacrificed and spleen indices were calculated. Spleen index= spleen weight (mg) × 10/body weight (g) × 100%. b Survival rate. P. berghei-infected mice (n  = 10) and those treated with 450 mM α-lactose (n  = 10) died between days 15 and 23 p.i. P. berghei-infected mice treated with 550 mM α-lactose (n  = 10) died between days 16 and 26 p.i. c Histopathological changes in the lung tissues detected using HE staining. d Histopathological changes in the spleen tissues detected using HE staining. e Histograms of the histopathological score and the area of hemosiderin in lung tissue. f Histograms of the histopathological score and the area of hemosiderin in spleen tissue. The results are representative of three independent experiments with five to seven mice in each group per experiment, with data denoting means ± SDs. *P < 0.05, **P < 0.01, ***P < 0.001. *indicates comparisons with the control group

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