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Table 6 Polymorphisms observed in each pvdbp-II epitope sequence

From: Genetic diversity, natural selection and haplotype grouping of Plasmodium vivax Duffy-binding protein genes from eastern and western Myanmar borders

Epitope nameEpitopeSMHHd ± SDπ ± SDdN-dSTajima’s D
5T/B1120.124 ± 0.0330.003 ± 0.0070.003− 0.308
16T/B1120.503 ± 0.0000.012 ± 0.0000.0161.942
18B1120.503 ± 0.0000.011 ± 0.0000.0141.942
20T/B1120.503 ± 0.0000.015 ± 0.0000.0191.942
45B5580.674 ± 0.0240.029 ± 0.0010.036*0.966
48B2230.266 ± 0.0390.007 ± 0.0010.008*− 0.333
66T1120.273 ± 0.0390.006 ± 0.0010.0080.576
IaMHC class I3340.491 ± 0.0410.028 ± 0.0030.034*0.757
IbMHC class I1120.024 ± 0.0160.001 ± 0.0010.001− 0.901
IcMHC class I1120.502 ± 0.0050.012 ± 0.0000.0151.937
IIaMHC class II1120.373 ± 0.0340.012 ± 0.0010.0161.169
IIbMHC class II2230.375 ± 0.0420.015 ± 0.0020.0180.181
  1. Notes: Epitope sequences are: 5 [299-VNNTDTNFH(R/S)DITFR-313]; 16 [321-LIYDAAVEGDLL(L/F)KL-335]; 18 [325-AAVEGDLL(L/F)KLNNYR-339]; 20 [329-GDLL(L/F)KLNNYRYNKD-343]; 45 [379-SIFGT(D/G)(E/K)(K/N)AQQ(R/H)(R/C)KQ-393]; 48 [385-(E/K)(K/N)AQQ(R/H)(R/C)KQWWNESK-399]; and 66 [421-ICK(L/I)NVAVNIEPQIY-435]. In silico predicted promiscuous epitopes: Ia [416-G(N/K)F(I/M)WICK(L/I)-424]; Ib [482-KSYD(Q/E)WITR-490]; Ic [497-VLSNKF(I/K)SVKNAEK-510]; IIa [408-YSVKKRLKG(N/K)-417]; and IIb [418-F(I/M)WICK(L/I)NV-426]
  2. Abbreviations: S, number of polymorphic (segregating) sites; M, total number of mutations; H, number of haplotypes; Hd, haplotype diversity; π, observed average pairwise nucleotide diversity; dN, rate of non-synonymous mutations; dS, rate of synonymous mutations; B, B-cell epitope; T, T-cell epitope; SD, standard deviation
  3. *P < 0.05