Table 3 List of the differentially expressed genes mapped to representative immune-related pathways by KEGG pathway analysis

Chemokine signaling

 1

ADCY9

Adenylate cyclase type 9

3.59

Up

 2

CCL11

C-C motif chemokine 11/eotaxin

9.56

Up

 3

CCL4

C-C motif chemokine 4

13.42

Up

 4

CCR5

C-C chemokine receptor type 5-like

4.31

Up

 5

CXCL12

Stromal cell-derived factor 1 precursor

3.0

Up

 6

CXCL13

C-X-C motif chemokine 13-like

4.99

Up

 7

CXCR1

C-X-C chemokine receptor type 1-like

4.47

Up

 8

CXCR3

C-X-C chemokine receptor type 3-like

− 2.49

Down

 9

CXCR5

C-X-C chemokine receptor type 5-like

2.64

Up

 10

FOXO3

Forkhead box O3

4.36

Up

 11

GNG13

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

3.53

Up

 12

PXN

Paxillin-like

3.11

Up

NOD-like receptor signaling

 1

ATG16L1

Autophagy related 16-like 1

2.88

Up

 2

ATG5

Autophagy related 5 homolog

4.89

Up

 3

CASR

Extracellular calcium-sensing receptor-like protein

3.26

Up

 4

CTSB

Cathepsin B

− 3.01

Down

 5

IFNAR1

Interferon alpha/beta receptor 1a-like

2.34

Up

 6

IFNAR2

Interferon alpha/beta receptor 2

2.72

Up

 7

JUN

Transcription factor AP-1-like

3.75

Up

 8

NLRP3

NACHT, LRR and PYD domains-containing protein 3

− 2.37

Down

 9

PYCARD

Apoptosis-associated speck-like protein containing a CARD

2.53

Up

 10

RIPK3

Receptor-interacting serine/threonine-protein kinase 3

2.70

Up

Natural killer cell mediated cytotoxicity

 1

BID

BH3-interacting domain death agonist-like

2.77

Up

 2

ICAM1

Intercellular adhesion molecule 1-like isoform X2

− 7.45

Down

 3

IFNAR1

Interferon alpha/beta receptor 1a-like

2.34

Up

 4

IFNAR2

Interferon alpha/beta receptor 2

2.72

Up

 5

IFNGR1

Interferon gamma receptor 1a

2.33

Up

 6

IGH

Immunoglobulin heavy chain

147.29

Up

 7

ITGB2

Integrin beta-2-like

3.0

Up

 8

PRF1

Perforin-1-like

− 3.18

Down

 9

PTPN11

Tyrosine-protein phosphatase non-receptor type 11

2.81

Up

Th17 cell differentiation

 1

CD3E

CD3epsilon

5.68

Up

 2

IFNGR1

Interferon gamma receptor 1a

2.33

Up

 3

IL21R

Interleukin-21 receptor-like

2.69

Up

 4

IL6ST

Interleukin-6 receptor subunit beta-like

3.28

Up

 5

IRF4

Interferon regulatory factor 4

7.28

Up

 6

JUN

Transcription factor AP-1-like

3.75

Up

 7

NFKBIE

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

9.05

Up

 8

TGFBR1

TGF-beta receptor type-1

− 2.14

Down

Hematopoietic cell lineage

 1

CD2

T-cell surface antigen CD2

2.89

Up

 2

CD22

B-cell receptor CD22-like

3.10

Up

 3

CD34

Hematopoietic progenitor cell antigen CD34-like

− 3.13

Down

 4

CD3E

CD3epsilon

5.68

Up

 5

CR2

Complement receptor type 2-like

3.25

Up

 6

IGH

Immunoglobulin heavy chain

147.29

Up

 7

MME

Neprilysin-like

− 4.06

Down

 8

TFRC

Transferrin receptor protein 1-like

4.97

Up

B cell receptor signaling

 1

BLNK

B-cell linker protein-like isoform X1

3.43

Up

 2

CD22

B-cell receptor CD22-like

3.10

Up

 3

CD79A

B-cell antigen receptor complex-associated protein alpha chain-like

2.76

Up

 4

CR2

Complement receptor type 2-like

3.25

Up

 5

IGH

Immunoglobulin heavy chain

147.29

Up

 6

JUN

Transcription factor AP-1-like

3.75

Up

 7

NFKBIE

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

9.05

Up

Th1 and Th2 cell differentiation

 1

CD3E

CD3 epsilon

5.68

Up

 2

IFNGR1

Interferon gamma receptor 1a

2.33

Up

 3

IL12B

Interleukin-12 subunit beta-like

2.31

Up

 4

IL12RB2

Interleukin-12 receptor subunit beta-2-like

3.50

Up

 5

JUN

Transcription factor AP-1-like

3.75

Up

 6

NFKBIE

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

9.05

Up

Complement and coagulation cascades

 1

A2M

Alpha-2-macroglobulin-like

− 7.82

Down

 2

C8G

Complement C8 gamma chain

− 5.78

Down

 3

CR2

Complement receptor type 2-like

3.25

Up

 4

F2RL2

Proteinase-activated receptor 3-like (coagulation factor II (thrombin) receptor)

5.81

Up

 5

ITGB2

Integrin beta-2-like

3.0

Up

 6

PLAUR

Urokinase plasminogen activator surface receptor-like

− 3.17

Down