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Table 3 DrenchRite LDA dose response data for macrocyclic lactones in Ancylostoma caninum isolates

From: Multiple drug resistance in the canine hookworm Ancylostoma caninum: an emerging threat?

Isolate LDA IC50 (nM) (95% CI) R2 LDA RR
ETCR 1.0 16.62 0.93  
Lacy 91.53 0.53 5.5
Worthy 1.0 1052 0.45 63.2
Barrow 1.0 12.31 (10.42–14.70) 0.98  
Worthy 4.1F3P 859 (411.3–3426) 0.92 69.8
  1. Notes: Initial assays were performed singly using ETCR 1.0, Lacy and Worthy 1.0 and subsequent assays were performed in triplicate using Barrow 1.0 and Worthy 4.1F3P, in order to improve the precision of the estimate and reduce the width of the 95% confidence intervals (CI). In all assays each ivermectin aglycone concentration was measured in duplicate. Resistance ratios (RR) were calculated as IC50 resistant isolate/IC50 susceptible isolate; RR are not provided for the susceptible isolates, as this value has no relevance
  2. Abbreviations: LDA, larval development assay