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Fig. 2 | Parasites & Vectors

Fig. 2

From: Gene copy number and function of the APL1 immune factor changed during Anopheles evolution

Fig. 2

Depletion of APL1 leads to mosquito mortality in Anopheles stephensi. Survival curves of An. stephensi depleted for APL1 activity by dsAPL1 treatment (red lines) as compared to dsGFP-treated controls (green lines) under different experimental conditions. a Sugar-fed mosquitoes. b Mosquitoes fed an uninfected normal blood meal. c Mosquitoes fed a Plasmodium yoelii-infected blood meal. d Mosquitoes treated with antibiotics and fed a P. yoelii-infected blood meal. Replicate experiments are distinguished by line type (plain, dashed or dotted, respectively). X-axis indicates time after the start of recording. A Cox proportional hazards regression model was fitted to the data using treatment and replicate as predictor terms. The P-value associated with the dsRNA treatment term of the Cox model is shown on each panel. Panel a Wald statistic = 4.195, df = 1, P = 2.75e−5; Panel b Wald statistic = 3.648, df = 1, P = 0.0003; Panel c Wald statistic = 8.376, df = 1, P < 2e−16; Panel d Wald statistic = 1.1518, df = 1, P = 0.129

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