From: Twenty-five-year research progress in hookworm excretory/secretory products
Molecule | GenBank | Size (aa) | Species | Stage | Location | Function | Reference |
---|---|---|---|---|---|---|---|
Ac-ASP-1 | Q16937 | 424 | A. caninum | L3 | Unknown | Larval migration | [15] |
Ac-ASP-2 | AAC35986 | 218 | A. caninum | L3 | Unknown | Larval migration | [16] |
Ace-ASP-1 | AAN11402 | 425 | A. ceylanicum | L3 | Unknown | Larval migration | [19] |
Ace-ASP-2 | AAP41953 | 217 | A. ceylanicum | L3 | Unknown | Larval migration | [19] |
Na-ASP-1 | AAD13340 | 424 | N. americanus | L3 | Unknown | Larval migration | [15] |
Na-ASP-2 | AY288089 | 210 | N. americanus | L3 | Unknown | Larval migration and immunomodulation | |
Ac-ASP-3 | AAO63575 | 200 | A. caninum | Adult | Pharyngeal and esophageal glands | Unknown | [30] |
Ac-ASP-4 | AAO63576 | 508 | A. caninum | Adult | Cuticle | Unknown | [30] |
Ac-ASP-5 | AAO63577 | 424 | A. caninum | Adult | Intestinal microvilli | Unknown | [30] |
Ac-ASP-6 | AAO63578 | 451 | A. caninum | Adult | Cephalic and excretory glands | Unknown | [30] |
Ac-APc2 | AAC47080 | 91 | A. caninum | Adult | Esophagus | Factor VIIa/tissue factor complex inhibitor anticoagulant | |
Ac-APc3 | AAP57305 | 84 | A. caninum | Adult | Esophagus | Factor VIIa/tissue factor complex inhibitor anticoagulant | [50] |
Ac-APc4 | AAP82926 | 99 | A. caninum | Adult | Esophagus | Factor VIIa/tissue factor complex inhibitor anticoagulant | [50] |
Ac-AP5 | U30795 | 100 | A. caninum | Adult | Cephalic glands | Factor Xa inhibitor anticoagulant | |
Ac-AP6 | AAC47081 | 98 | A. caninum | Adult | Unknown | Factor Xa inhibitor anticoagulant | [43] |
Ac-AP12 | ADR77824 | 100 | A. caninum | Adult | Esophagus | Factor Xa inhibitor anticoagulant | [51] |
Ac-NAP10 | ABP88128 | 90 | A. caninum | Adult | Unknown | VIIa/tissue factor complex and Xia factor inhibitor anticoagulant | [52] |
Adu-NAP4 | ACD80355 | 104 | A. duodenale | Adult | Unknown | Xa and Xia factors inhibitor anticoagulant | [53] |
Ace-NAP1 | AAK81733 | 102 | A. ceylanicum | Adult | Unknown | VIIa/tissue factor complex and Xa factor inhibitor anticoagulant | [48] |
Ac-HPI | AF399709 | 181 | A. caninum | Adult | Cephalic glands | Platelet inhibitor | [47] |
Ace-HPI | MK087839 | 200 | A. ceylanicum | Adult | Esophagus; cephalic glands | Platelet inhibitor | [61] |
Ac-APR-1 | AAB06575 | 442 | A. caninum | Adult and L3 | Intestinal microvilli; esophagus; excretory/amphidial glands | Hb, serum, and connective tissue proteins digestion | |
Na-APR-1 | na | na | N. americanus | Adult and L3 | Intestinal microvilli; esophagus; excretory/amphidial glands | Hb, serum, and connective tissue proteins digestion | |
Us-APR-1 | ACI02330 | 447 | U. stenocephala | Adult | Unknown | Hb digestion | [67] |
Na-APR-2 | Q9N9H4 | 425 | N. americanus | Adult | Gut lumen; amphidial and excretory glands | Hb and serum proteins digestion | [68] |
Ac-CP-1 | U18911 | 343 | A. caninum | Adult | Esophageal, cephalic and excretory glands | Intestinal mucosal plug digestion | [70] |
Ac-MTP-1 | AAK62032 | 547 | A. caninum | L3 | Esophageal glands | Larval migration | |
Ace-MTP-2 | ABG49116 | 233 | A. ceylanicum | Adult | Esophageal glands | Intestinal tissue degradation and immunomodulation | [74] |
Ace-KI-1 | AAD51334 | 84 | A. ceylanicum | Adult | Subcuticle | Immunomodulation and host proteases inhibition | |
Ac-KPI-1 | AAN10061 | 759 | A. caninum | Adult | Unknown | Unknown | [81] |
Adu-TIL-1 | GU951574 | 161 | A. duodenale | Adult | Cuticle; esophagus; intestine | Neutrophil elastase and trypsin digestion | [82] |
Ac-API-1 | AAU29500 | 228 | A. caninum | Adult | Pseudocoelomic fluid | Unknown | [87] |
Ac-TMP-1 | AF372652 | 140 | A. caninum | Adult | Unknown | Ac-MTP-1 inhibitor and immunomodulator | [83] |
Ac-TMP-2 | ACB13195 | 244 | A. caninum | Adult | Cephalic and esophageal glands | MMP inhibitors | [84] |
Na-GST-1 | FJ711440 | 206 | N. americanus | Adult | Esophagus; muscles; hypodermis; gut | Heme and hematin detoxification | [90] |
Na-GST-2 | FJ711441 | 206 | N. americanus | Adult | Buccal capsule; weakly in cuticle and gut | Heme and hematin detoxification | [90] |
Na-GST-3 | FJ711442 | 206 | N. americanus | Adult | Buccal capsule; weakly in cuticle and gut | Heme and hematin detoxification | [90] |
Ac-GST-1 | AY605283 | 207 | A. caninum | Adult | Hypodermis; muscle; weakly in intestine | Heme and hematin detoxification | [93] |
Ace-GST | MN103336 | 155 | A. ceylanicum | Adult | Cuticle; muscle; intestine | Heme and hematin detoxification | [94] |
SOD | na | na | N. americanus | Adult | Unknown | Antioxidant | [104] |
Ace-PRX-1 | JX124321 | 196 | A. ceylanicum | Adult | Unknown | Antioxidant and immunomodulatora | [89] |
Ac-NIF | AAA27789 | 274 | A. caninum | Adult | Unknown | Immunomodulation | [11] |
Ace-MIF | ABO31935 | 119 | A. ceylanicum | Adult and L3 | Unknown | Immunomodulation | [120] |
Calreticulin | AJ006790 | 403 | N. americanus | Adult | Unknown | Complement binder and immunomodulator | |
Ace-ES-1 | AAL02424 | 109 | A. ceylanicum | Adult | Unknown | Unknown | [124] |
Ace-ES-2 | AAS13463 | 102 | A. ceylanicum | Adult | Unknown | Unknown | [125] |
Na-CTL-2 | AF388311 | 178 | N. americanus | Adult | Unknown | Immunomodulationa | [131] |
Ace-CTL-1 | AF172652 | 184 | A. ceylanicum | Male | Testis in male; embryo in female | Hookworm reproduction | [128] |
Na-AChE | na | na | N. americanus | Adult | Amphidial and esophageal glands | Unknown | |
Ac-FAR-1 | AAM93667 | 181 | A. caninum | Adult | Unknown | Fatty acid and retinol uptake | [143] |
Ac-FAR-2 | AAM97930 | 181 | A. caninum | Adult | Unknown | Fatty acid and retinol uptake | [143] |
Ace-FAR-1 | EU449764 | 181 | A. ceylanicum | Adult | Hypodermis; uterus; ovaries; testis | Fatty acid uptake for cuticle, egg and embryo development | [144] |
Na-FAR-1 | 4UET | 175 | N. americanus | Adult | Intestine; male bursa | Nutrient uptake and male reproduction | [146] |
Ace-NPA | na | na | A. ceylanicum | All stages | Pseudocoelom; cuticle; hypodermis; testis | Fatty acids uptake for cuticle integrity and male reproduction | [147] |