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Fig. 1 | Parasites & Vectors

Fig. 1

From: Identification and characterization of an R-Smad homologue (Hco-DAF-8) from Haemonchus contortus

Fig. 1

Amino acid sequence alignment of Haemonchus contortus Hco-DAF-8 with those of 10 R-Smads from selected species, including one nematode (Caenorhabditis elegans), one arthropod (Drosophila melanogaster) and three chordates (Danio rerio, Homo sapiens and Mus musculus). Sequence motifs, such as MH1 (pink), MH2 (blue) and the phosphorylation motif (****) are marked. Within the MH1 region, the predicted nuclear localisation signal (NLS) is underlined. Within the linker region between the MH1 and the MH2 domain of Hco-DAF-8, prolines (yellow) and SP motifs (open squares) which function as target sites for phosphorylation via intracellular serine/threonine kinases are highlighted. Within the MH2 domain, black arrow indicates the conserved residues involved in TGF-β/Activin-activated R-Smads interaction with SARA; open circle indicates conserved residues of the nuclear export signal. The L3 loop sequence (18 amino acids) is shown (wavy line below the alignment) with R-Smad subtype-specific amino acid residues highlighted with red arrows at the top. The sequence percent identities (%) of Hco-DAF-8 with the other R-Smads are listed at the end of the alignment. Information on sequences in the alignment is listed in Additional file 1: Table S2

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