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Fig. 1 | Parasites & Vectors

Fig. 1

From: Dafachronic acid and temperature regulate canonical dauer pathways during Nippostrongylus brasiliensis infectious larvae activation

Fig. 1

Dafachronic acid is an agonist of N. brasiliensis DAF-12. aIn vitro, both Δ7-dafachronic acid (Δ7-DA) and Δ4-dafachronic acid (Δ4-DA) act as agonists for N. brasiliensis nuclear hormone receptor Nbr-DAF-12, although Δ4-dafachronic acid is a weaker agonist. b In comparison to other clade V/clade 9 nematode species, N. brasiliensis DAF-12 responds more weakly to Δ7-dafachronic acid than DAF-12 from either the canine hookworm A. caninum (Aca-DAF-12) or the free-living C. elegans (Cel-DAF-12). a, b Co-transfection assays were performed in HEK293 cells in biological triplicate; luciferase activity was quantified in relative light units and the maximal reading observed scaled to 100%. Data represent the mean ± standard deviation of triplicate assays

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Parasites & Vectors

ISSN: 1756-3305

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