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Fig. 2 | Parasites & Vectors

Fig. 2

From: Angiostrongylus cantonensis Galectin-1 interacts with Annexin A2 to impair the viability of macrophages via activating JNK pathway

Fig. 2

AcGal-1 induces macrophage apoptosis. a Flow cytometry analysis showing that apoptosis (revealed by the levels of Annexin V and PI) in AcGal-1-treated macrophages was higher than that in BSA-treated cells (control). b Quantitation of the percentage of Annexin V+ cells. c Expression levels of proteins associated with apoptosis/anti-apoptosis as determined by western blot in different cell groups (control, BSA and AcGal-1). AcGal-1 induced macrophage apoptosis by increasing the levels of cleaved caspase-3, -9, Bax, and decreasing the expression level of Bcl-2. d Quantitation of expression intensity of each protein. e AcGal-1 increased the enzymatic activity of caspase-3 in macrophages, treated as in b. Data represent the mean ± standard deviation (SD; vertical bars) of triplicate experiments. *P < 0.05, **P < 0.01, ***P < 0.001

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