Plasmodium vivax HAP2/GCS1 gene exhibits limited genetic diversity among parasite isolates from the Greater Mekong Subregion

Table 2 Nucleotide diversity and summary statistics of pvhap2 in the three GMS P. vivax populations

Locality	S	η	NS	SP	k	π ± SD	H	Hd ± SD
China-Myanmar border (n = 135)	10	10	7	3	0.589	0.00023 ± 0.00003	11	0.420 ± 0.052
Myanmar (n = 51)	17	17	9	8	1.363	0.00053 ± 0.00009	18	0.747 ± 0.057
Thailand (n = 41)	11	11	6	5	1.110	0.00043 ± 0.00007	9	0.705 ± 0.059
Total (n = 227)	28	28	16	12	0.924	0.00036 ± 0.00003	29	0.620 ± 0.032

Abbreviations: S, number of segregating sites; η, the total number of mutations; NS, number of non-synonymous polymorphisms; SP, number of synonymous polymorphisms; k, the average number of nucleotide differences; π, pairwise nucleotide diversity; H, number of haplotypes; Hd, haplotype diversity
Note: The extent of pvhap2 gene sequence corresponded to nucleotides 13–2574 bp (codons 5–858, reference clone Sal I)

ISSN: 1756-3305