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Table 3 Distribution of Borrelia persica and Borrelia burgdorferi sensu stricto spirochetes in tissues of immunodeficient NOD-SCID mice on day 49/50

From: Rapid clearance of Borrelia burgdorferi from the blood circulation

Inoculuma

n

Spirochetes in tissue samples detected by culture/qPCR (organisms/mg)

Ear

Skin

Joint

Spleen

Bladder

Heart

Brain

Intradermal

 B. persica (1.0 × 105)

 

#/0

#/17

#/199

+/873

+/74,518

+/14,017

+/3702

#/0

#/47,690

#/117

#/19

#/1743

#/46,102

#/10,721

#/0

#/11,529

+/262

−/3381

+/83,700

+/23,582

+/11,929

#/0

#/1171

#/574

+/1050

+/26,254

#/28,797

+/2639

#/0

#/311

#/24

#/144

#/131,872

#/6168

#/1896

 Positive mice

3/5

0/0

0/5

1/5

2/5

3/5

2/5

3/5

Intradermal

 B. burgdorferi sensu stricto (1.0 × 106)

 

#/48

#/41,467

+/20,395

+/22

+/266,594

+/360

+/11

#/522

#/18,795

+/37,393

+/537

+/217,600

#/333

+/12

#/3082

#/16,655

#/2113

#/14

+/2,110,835

+/357

+/15

#/10,372

#/18,435

+/40,571

#/3

+/1,141,583

+/1122

+/47

#/4,987

#/15,288

+/17,693

+/992

+/384,204

+/2057

+/12

 Positive mice

5/5

0/5

0/5

4/5

3/5

5/5

4/5

5/5

  1. aCulture-derived borreliae
  2. Key: #, contaminated culture; +, positive, with motile spirochetes in culture; −, negative, no spirochetes in culture