Fig. 1

Treatment of rSj-Cys improved the sepsis-induced myocardial malfunction. Representative M-mode echocardiograms obtained from mice 12 h after treatment of sham-operation, sham + rSj-Cys, CLP and CLP + rSj-Cys, respectively (a). The improved left ventricular systolic function evaluated by EF and FS after treatment with rSj-Cys (c). The improved CLP-induced left ventricular diastolic dysfunction was shown as representative transmitral Doppler images. The E wave represents peak early-diastolic transmitral velocity, and the A wave indicates peak late-diastolic transmitral velocity (b). The changes of the E/A ratio were used to assess the alteration in left ventricular diastolic function (d). (n = 6 mice per group). Data are presented as the mean ± SE. ***P < 0.001