Fig. 3

Xiaochaihu (XCH) decoction inhibited Schistosoma japonicum induced upregulation of hepatic fibrogenic genes. Total RNA and protein were extracted from mouse livers after S. japonicum infection and treatment with Xiaochaihu decoction. a The changes of TGF-β1, HSP47, α-SMA, Col III and Col I mRNA levels of S. japonicum-infected mouse liver were assessed by quantitative real-time PCR. b Hepatic protein levels of Col I, α-SMA, TGF-β1, HSP47 and Col III were assessed by western blot. Abbreviations: M, Model, S. japonicum infection; XCH-L (M, H), Xiaochaihu decoction low (middle, high) dose. P < 0.05, **P < 0.01