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Fig. 4 | Parasites & Vectors

Fig. 4

From: Xiaochaihu decorction relieves liver fibrosis caused by Schistosoma japonicum infection via the HSP47/TGF-β pathway

Fig. 4

Xiaochaihu (XCH) decoction inhibited Schistosoma japonicum induced fibroblast activation. a Quantitative real-time PCR showed that S. japonicum egg antigens induced upregulation of HSP47, TGF-β1, Timp-1, α-SMA, Col1A1 and Col3A1 in NIH3T3 fibroblasts, which was inhibited by XCH, TGF-β receptor inhibitor LY2157299, and shRNA targeting Hsp47. b The changes of α-SMA, HSP47, Timp-1, Col 1 and Col 3 protein level in NIH3T3 fibroblasts under specified treatments were evaluated by western blot. Abbreviations: SJ-A, S. japonicum egg antigens; LY, LY2157299. *P < 0.05, **P < 0.01 compared to the control, #P < 0.05, ##P < 0.01 compared to S. japonicum egg antigens

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