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Fig. 5 | Parasites & Vectors

Fig. 5

From: H1-antihistamines as antischistosomal drugs: in vitro and in vivo studies

Fig. 5

Effect of H1-antihistamine drugs on the egg developmental stage in a preclinical mouse model. Drugs were administered orally using a single dose of 400 mg/kg or 100 mg/kg for five consecutive days to mice harboring either early or chronic S. mansoni infection. On day 56 post-infection, all animals were humanely euthanized and egg burdens were determined by counting eggs in the intestine (quantitative and qualitative oogram technique). Data are presented as the mean ± SD (n = 5 per group). The numbers represent the percentages of egg reduction vs infected untreated control. *P   < 0.05, **P   < 0.01, ***P   < 0.001 compared with infected untreated control groups. Abbreviations: CNZ, cinnarizine; DES, desloratadine; RUP, rupatadine

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