Fig. 7
From: H1-antihistamines as antischistosomal drugs: in vitro and in vivo studies
Effect of H1-antihistamine drugs on the organ pathology in a preclinical mouse model. a Liver weight. b Spleen weight. Drugs were administered orally using a single dose of 400 mg/kg or 100 mg/kg for five consecutive days to mice harboring either early or chronic S. mansoni infection. On day 56 post-infection, all animals were humanely euthanized and organ pathology was determined by liver and spleen weights. Data are presented as the mean ± SD (n = 5 per group). The numbers represent the percentages of egg reduction vs infected untreated control. *P < 0.05, **P < 0.01, ***P < 0.001 compared with infected untreated control groups by Dunnett’s test. Abbreviations: OWR, organ weight reduction; CNZ, cinnarizine; DES, desloratadine; RUP, rupatadine