Fig. 1From: Proteomic signatures of metronidazole-resistant Trichomonas vaginalis reveal novel proteins associated with drug resistanceA schematic diagram of experimental workflow. To explore the underlying mechanism of MTZ resistance, we conducted quantitative proteomic analysis to profile global proteomes of MTZ-S and MTZ-R parasites. iTRAQ combined with LC-MS/MS analysis were performed to identify the differentially expressed proteins in the MTZ-R proteome. Functional annotations, protein-protein interaction networks and pathway enrichment analysis of the differentially expressed proteins were analyzed by GO, STRING and GESA, respectively. Proteins potentially associated with MTZ resistance were selected for experimental validationBack to article page