Fig. 3

Network and enrichment analysis of the most differentially expressed proteins in the MTZ-R proteome upon MTZ treatment. Using STRING analysis, the protein-protein interaction networks were obtained upon entering the most upregulated proteins ankyrin 2,3/unc44 (TVAG_465440) (a), receptor expression-enhancing protein (TVAG_232140) (b) and histidinol-phosphate aminotransferase (TVAG_108400) (c), as well as the most downregulated proteins glucose kinase (TVAG_442070) (d), iron-sulfur flavoprotein (TVAG_370510) (e), and NAD(P)H dehydrogenase (TVAG_311580) (f) in the MTZ-R proteome in response to MTZ. As shown at the bottom of each panel, the enriched functions of the networks have been identified, and the corresponding protein nodes in the networks were automatically highlighted in colors