Fig. 4

Differentially expressed proteins involved in the hydrogenosomal energy metabolism of the MTZ-R proteome. The protein expression changes between the MTZ-R and MTZ-S proteomes treated with MTZ (MTZ-MTZ-R/MTZ-S; I) or without MTZ (MTZ-R/MTZ-S; II) were presented as fold change. Proteins shown in red and green color indicate upregulation and downregulation, respectively. Complex I, also known as NADH dehydrogenase, is composed of two subunits (24 kDa subunit: TVAG_296220; 51 kDa subunit: TVAG_072700 and TVAG_489800). Abbreviations: ME, malic enzyme; Fd, ferredoxin; PFOR, pyruvate:ferredoxin oxidoreductase; ASCT, acetyl:succinate CoA-transferase; STK, succinate thiokinase