Fig. 5
Enrichment analysis of differentially expressed proteins reveals enriched gene sets in the MTZ-R proteome upon MTZ treatment. A total of 3123 proteins ranked by fold change in protein expression (MTZ-R proteome compared with that of MTZ-S) were subjected to GSEA. Enrichment score (ES) reflects the degree of a gene set to be overrepresented at the top or bottom of a ranked list of genes. The positive ES and negative ES indicate upregulation and downregulation of a specific gene set, respectively. The enrichment plots using KEGG as the database presented the top 3 upregulated (a) or downregulated (b) pathways in the MTZ-R proteome upon MTZ treatment. The enrichment plots using GO as the database showed the top 3 enriched GO terms of the upregulated (c) or downregulated (d) gene sets in the MTZ-R proteome upon MTZ treatment