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Table 1 Alkaloid average IC50, TC50 and SI values for Vero and HepG2 cells

From: Amaryllidaceae alkaloids with anti-Trypanosoma cruzi activity

Alkaloid

IC50 (µM)

TC50 (µM)a

SIa

TC 50 (µM)b

SIb

BNZ

1.56

173.4

111.15

168.76

108.18

Lycorine

0.70

5.21

7.44

21.87

31.24

Hippeastrinec

3.63

45.99

12.67

128.10

35.29

Crinine

57.93

–

 

–

 

Haemanthamine

1.59

11.52

7.25

42.48

26.72

Narciclasine

0.49

0.66

1.33

2.73

5.52

Tazettine

83.03

–

 

–

 

Montanine

1.99

5.04

2.53

46.10

23.17

Sanguinine

213.40

–

 

–

 

1-O-acetylcaranine

35.49

–

 

–

 
  1. aVero cell toxicity assay
  2. bHepG2 cell toxicity assay
  3. cThe only alkaloid evaluated in this study that showed specific anti-T. cruzi activity
  4. Note: The standard drug BNZ is included in the first line for comparison
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Parasites & Vectors

ISSN: 1756-3305

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