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Table 1 Efficacy of oral moxidectin against ML-resistant heartworms compared to Heartgard® Plus or Interceptor® Plus: study designs

From: Preventive efficacy of four or six monthly oral doses of 24 µg/kg moxidectin compared to six monthly doses of Heartgard® Plus or Interceptor® Plus against macrocyclic lactone-resistant heartworm (Dirofilaria immitis) strains in dogs

Group Treatment Oral dosage No. of dogs Day of L3D. immitis inoculationa Days of treatment Days of blood microfilariae and adult D. immitis antigen testingb Day of necropsy and adult D. immitis worm recovery
T01 Negative control na 6 -30 0, 30, 60, 90, 120, 150 -36 or -30, 60, 180, 210, 236 or 243 237 or 243
T02 Moxidectin 24 µg/kg 6 -30 0, 30, 60, 90
T03 Moxidectin 24 µg/kg 6 -30 0, 30, 60, 90, 120, 150
T04 Heartgard® Plus Min. of 6 µg/kgc 6 -30 0, 30, 60, 90, 120, 150
T05 Interceptor® Plus Min. of 500 µg/kgc 6 -30 0, 30, 60, 90, 120, 150
  1. aEach dog was inoculated with 50 infective L3 of D. immitis of either ZoeLA (Study 1) or JYD-34 (Study 2)
  2. bDay 180 testing only conducted in Study 2
  3. cHeartgard® Plus and Interceptor® Plus administered at their approved dosages according to their commercial label directions