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Table 4 Adult D. immitis antigen and microfilariae test results (JYD-34 strain)

From: Preventive efficacy of four or six monthly oral doses of 24 µg/kg moxidectin compared to six monthly doses of Heartgard® Plus or Interceptor® Plus against macrocyclic lactone-resistant heartworm (Dirofilaria immitis) strains in dogs

Treatment group

Oral dosage

Days of treatment

Individual

Day -30

Day 60

Day 180

Day 210

Day 236

Ag

MF

Ag

MF

Ag

MF

Ag

MF

Ag

MF

Negative control

na

0, 30, 60, 90, 120, 150

1

+

+

+

+

+

+

2

+

+

+

+

+

+

3

+

+

+

+

+

+

4

+

+

+

+

+

+

5

+

+

+

+

+

+

6

+

+

+

+

+

+

Moxidectin

24 µg/kg

0, 30, 60, 90

1

+

+

2

+

+

3

4

+

+

+

5

+

+

6

+

Moxidectin

24 µg/kg

0, 30, 60, 90, 120, 150

1

2

3

4

5

6

+

+

Heartgard® Plus

Min of 6 µg/kga

0, 30, 60, 90, 120, 150

1

+

+

+

+

+

+

2

+

+

+

3

+

+

+

+

+

+

4

+

+

+

+

+

5

+

+

+

+

+

+

6

+

+

+

Interceptor® Plus

Min. of 500 µg/kgb

0, 30, 60, 90, 120, 150

1

+

+

+

+

+

+

2

+

+

+

+

+

+

3

+

+

+

+

+

+

4

+

+

+

+

5

+

+

+

+

+

+

6

+

+

+

+

+

  1. aHeartgard® Plus (ivermectin + pyrantel pamoate) administered according to commercial label directions which resulted in administration of 6.0–11.8 µg/kg of ivermectin
  2. bInterceptor® Plus (milbemycin oxime + praziquantel) administered according to commercial label directions which resulted in administration of 0.5–1.0 mg/kg milbemycin oxime
  3. Abbreviations: Ag, adult D. immitis antigen test; MF, D. immitis microfilariae test; −, negative; +, positive