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Table 4 Adult D. immitis antigen and microfilariae test results (JYD-34 strain)

From: Preventive efficacy of four or six monthly oral doses of 24 µg/kg moxidectin compared to six monthly doses of Heartgard® Plus or Interceptor® Plus against macrocyclic lactone-resistant heartworm (Dirofilaria immitis) strains in dogs

Treatment group Oral dosage Days of treatment Individual Day -30 Day 60 Day 180 Day 210 Day 236
Ag MF Ag MF Ag MF Ag MF Ag MF
Negative control na 0, 30, 60, 90, 120, 150 1 + + + + + +
2 + + + + + +
3 + + + + + +
4 + + + + + +
5 + + + + + +
6 + + + + + +
Moxidectin 24 µg/kg 0, 30, 60, 90 1 + +
2 + +
3
4 + + +
5 + +
6 +
Moxidectin 24 µg/kg 0, 30, 60, 90, 120, 150 1
2
3
4
5
6 + +
Heartgard® Plus Min of 6 µg/kga 0, 30, 60, 90, 120, 150 1 + + + + + +
2 + + +
3 + + + + + +
4 + + + + +
5 + + + + + +
6 + + +
Interceptor® Plus Min. of 500 µg/kgb 0, 30, 60, 90, 120, 150 1 + + + + + +
2 + + + + + +
3 + + + + + +
4 + + + +
5 + + + + + +
6 + + + + +
  1. aHeartgard® Plus (ivermectin + pyrantel pamoate) administered according to commercial label directions which resulted in administration of 6.0–11.8 µg/kg of ivermectin
  2. bInterceptor® Plus (milbemycin oxime + praziquantel) administered according to commercial label directions which resulted in administration of 0.5–1.0 mg/kg milbemycin oxime
  3. Abbreviations: Ag, adult D. immitis antigen test; MF, D. immitis microfilariae test; −, negative; +, positive