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Table 5 Efficacy of oral moxidectin (24 µg/kg) compared to Heartgard® Plus or Interceptor® Plus (JYD-34 strain)

From: Preventive efficacy of four or six monthly oral doses of 24 µg/kg moxidectin compared to six monthly doses of Heartgard® Plus or Interceptor® Plus against macrocyclic lactone-resistant heartworm (Dirofilaria immitis) strains in dogs

Treatment

Oral dosage

Days of treatment

No. of infected dogsa

Adult D. immitis worm counts

Efficacy compared to negative controlc

Individual worm counts

Geometric meanb

% Reduction

Negative Control

NA

0, 30, 60, 90, 120, 150

6 of 6

30, 33, 33, 33, 35, 37

32.9f

na

Moxidectin

24 µg/kg

0, 30, 60, 90

5 of 6

0, 1, 1, 2, 2, 4

1.3g

95.9

Moxidectin

24 µg/kg

0, 30, 60, 90, 120, 150

2 of 6

0, 0, 0, 0, 1, 1

0.2h

99.3

Heartgard® Plus

min of 6 µg/kgd

0, 30, 60, 90, 120, 150

6 of 6

6, 9, 13, 14, 17, 18

11.9i

63.9

Interceptor® Plus

min. of 500 µg/kge

0, 30, 60, 90, 120, 150

6 of 6

10, 13, 14, 16, 19, 22

14.9i

54.6

  1. aEach dog was inoculated with 50 infective JYD-34 L3 of D. immitis on Day -30
  2. bGeometric mean counts with the same superscript letters (f-i) are not significantly different (P ≥ 0.05)
  3. cAll dogs were necropsied for recovery of adult D. immitis on Day 237 (267 days post-inoculation)
  4. dHeartgard® Plus (ivermectin + pyrantel pamoate) administered according to commercial label directions which resulted in administration of 6.0 to 11.8 µg/kg of ivermectin
  5. eInterceptor® Plus (milbemycin oxime + praziquantel) administered according to commercial label directions which resulted in administration of 0.5 to 1.0 mg/kg milbemycin oxime